ANNUAL FINANCIAL REPORT 2010 2010 - TiGenix

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Title“Cell populations having imunoregulatory activity, method forisolation and uses” WO2007039150“Use of adipose tissue derived mesenchymal stem cells for thetreatment of graft versus host disease” WO2007065927Country/regionAustraliaIndiaNew ZealandRussian FederationEuropeCanadaMexicoSingaporeUSAChinaJapanIsraelHong KongSouth KoreaAustraliaIndiaEuropeEuropePatent Number (granted patent)/Application Publication Number (publishedapplications) or Application Number(unpublished applications).Granted patents highlighted in bold.AU2006261383184/KOLNP/2008NZ565246RU2008102643EP2292737CA2623353Application Number: MX/a/2008/003881SG165418US2009130067CN101313062JP2009508507IL1903631124884AKR20080048555AU2006299144Application Number: 1410/KOLNP/2008EP1926813EP1974019USUS20090148419“Injection Device” WO/2009/141727 EP EP09750184US PendingJPPending“Use of mesenchymal stem cells” WO/2010/015929 EP WO/2010/015929 (Application number:EP09786159)USWO/2010/015929 (Application number: US13/057467 )JPWO/2010/015929 (Application number: Pending)KR WO/2010/015929 (Application number: 10-2011-7005274)AUWO/2010/015929 (Application number:2009278853)CA WO/2010/015929 (Application number: 2,732,908)“Cell populations having imunoregulatory activity, methods for the WOWO2005/094353preparation and uses thereof.” WO2005/094353“Compositions comprising adipose stem cells.” WO/2010/070141 WO WO/2010/070141“Cells, nucleic acid constructs, cells comprising said constructsWOWO/2010/052313and methods utilizing said cells in the treatment of diseases. “WO/2010/052313“Methods for the preparation of adipose derived stem cells andWOWO/2010/063743utilizing said cells in the treatment of diseases.” WO/2010/052313“Methods and compositions for use in cellular therapies.”WOWO/2011/004264WO/2011/004264Methods for the preparation of cellular therapies. (Unpublished) GB Unpublished priority filing, application numberGB1012186.1Stem cell culture media and methods. (Unpublished) EP Unpublished priority filing, application numberEP10382244Methods and compositions for use in cellular therapies. EP Unpublished priority filing, application number EP11250025“Cell populations having imunoregulatory activity, methods for thepreparation and uses” (Unpublished)EPUnpublished priority filing, application numberEP11157930239 •
C. Trademarks of TiGenix and its subsidiaries (excluding Cellerix)The table below gives an overview of the registered trademark portfolio of TiGenix and its subsidiaries (excluding Cellerix):Mark Country Classes Filing date Registration date Renewal dateChondroCelect Austria 5-10-42 14/11/2001 14/11/2001 14/11/2011Benelux 5-10-42 18/5/2001 18/5/2001 18/5/2011Canada 5-10-42 14/11/2001Denmark 5-10-42 14/11/2001 14/11/2001 14/11/2011Finland 5-10-42 14/11/2001 14/11/2001 14/11/2011France 5-10-42 14/11/2001 14/11/2001 14/11/2011Germany 5-10-42 14/11/2001 14/11/2001 14/11/2011Italy 5-10-42 14/11/2001 14/11/2001 14/11/2011Norway 5-10-42 14/11/2001 14/11/2001 14/11/2011Spain 5-10-42 14/11/2001 14/11/2001 14/11/2011Sweden 5-10-42 14/11/2001 14/11/2001 14/11/2011Switzerland 5-10-42 14/11/2001 14/11/2001 14/11/2011United Kingdom 5-10-42 14/11/2001 14/11/2001 14/11/2011United States 5-10-42 16/11/2001 9/5/2006 9/5/2016TiGenix Austria 5-42 3/10/2000 3/10/2000 3/10/2010Benelux 5-10-41-42 10/4/2000 10/4/2000 10/4/2010Canada 5-42 3/10/2000Croatia 5-42 5/10/2000 5/10/2000 5/10/2010Denmark 5-42 3/10/2000 3/10/2000 3/10/2010Finland 5-42 3/10/2000 3/10/2000 3/10/2010France 5-42 3/10/2000 3/10/2000 3/10/2010Germany 5-42 3/10/2000 3/10/2000 3/10/2010Italy 5-42 3/10/2000 3/10/2000 3/10/2010Norway 5-42 3/10/2000 3/10/2000 3/10/2010Spain 5-42 3/10/2000 3/10/2000 3/10/2010Sweden 5-42 3/10/2000 3/10/2000 3/10/2010Switzerland 5-42 3/10/2000 3/10/2000 3/10/2010United Kingdom 5-42 3/10/2000 3/10/2000 3/10/2010United States 1-5 5/10/2000 22/11/2005 22/11/2015ChondroBoost Benelux 5-10-42 23/10/2006 23/10/2006 23/10/2016CCI Benelux 5-10-42 23/10/2006 23/10/2006 23/10/2016US 1, 5, 10, 42, 45 23/10/2006 04/08/2009 04/08/2019MeniscoCelect Community 5-10-42 24/7/2007 24/7/2007 24/7/2017US 1, 5, 10, 42, 45 24/7/2007 04/08/2009 04/08/2019CCH Benelux 5-10-44 04-03-2010 24-06-2010 04-03-2020US 10-44-42 04-03-2010Canada 5-10-42 04-03-2010Community 5-10-42 01-09-2010ChondroMimeticApplication filed240 • TiGenix • Rights Offering
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TiGenix NV(Public limited liability
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Table of ContentsSummary ..........
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3.7.1 Categories of potential inves
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5.7.1 Shares and warrants held by i
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7.5.2 Taxation.....................
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SummaryThe words written in capital
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Activities and strategy of the Comp
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• Two allogeneic adult stem cell
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• TiGenix’ success depends on i
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Unaudited pro forma income statemen
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Recent developmentsAcquisition of C
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In this context, we would like to s
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Announcement of the results of theO
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After the Contribution andafter the
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ContributionContribution AgreementC
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Risk factorsAny investment in the P
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commercialisation of ChondroCelect,
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in delays in bringing products to t
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The Company cannot predict what eff
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y each of its patents and patent ap
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to exercise preferential subscripti
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this prospectus which is capable of
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• investment professionals fallin
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1. General information and informat
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1.4.2 Company documents and otherin
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• the granting of discharge of li
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• in case of registered Shares, t
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cast at the meeting. If the amount
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No one may cast a greater number of
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If a Belgian resident individual ne
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Belgium has concluded tax treaties
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3. Information on the Contributiona
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In this context, we would like to s
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TiGenix has a limited financial deb
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Thousands of Euro (€) TiGenix Cel
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3.5.2 Issuance Price and RatioThe i
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(c)Rules for subscriptionSubject to
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The Scrips Private Placement will o
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to comply with any of its obligatio
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3.11.2 Scenario 1: Existing Shareho
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• a pledge of Locked Shares to a
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4. General information about THECOM
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DateINCORPORATIONFebruary 21,2000Tr
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Upon completion of the IPO of TiGen
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Issue dateMay 14,2004April 20,2005T
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4.7.2 Voting rightsAs further descr
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can be obtained free of charge at t
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5.2.4 Composition of the Board of D
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Amonis. Mr. Duron has been CEO of K
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5.3.4 Nomination and remunerationco
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• investor relations: nurturing c
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The remuneration of the members of
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5.7.2 Shares and warrants held by e
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Cellerix EBIP 2010An EBIP for senio
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The minutes must also contain a jus
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6. Activities of Tigenix andits sub
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• Clinical stage pipeline. TiGeni
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6.3.3 Acquisition of CellerixAs a r
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Full thickness articular cartilage
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Fig. 6.2: Autologous Chondrocyte Im
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Preclinical work in a meniscus repa
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The Company is also ensuring high q
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Recognising the importance of pre-l
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In Spain, since the passage of Orde
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Fig. 6.6: ChondroMimetic procedure
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6.5.3 Commercial strategyBuilding o
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6.7 Manufacturing & logisticsEffici
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The international application WO06/
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ChondroMimetic competitionThe main
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in Cellerix’ GMP facility in Madr
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6.14.3 History and development of C
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The table below gives an overview o
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Prevalence No. of cases (2010) Esti
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Fig. 6.9: Platform development stra
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In developing Cx601, Cellerix has b
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6.14.6 Manufacturing & logisticsCel
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population, methods for the isolati
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• Cimzia (certolizumab) - UCB: Al
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Spanish Ministry of Education and S
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7.2 Consolidated income statementTw
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7.3.1.2 Research and development ex
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7.3.2.3 Selling, general and admini
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7.4.1 Cash flows from operating act
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Cash & cash equivalents and intangi
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As of December 31, 2010, the Group
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8. Consolidated Financial informati
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8.1.3 Consolidated cash flow statem
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8.1.5 Notes to consolidated financi
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operating results and operating pla
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The Group does not account for work
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8.1.5.4 Operating result (EBIT)Resu
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8.1.5.7 TaxesThere is no current ta
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8.1.5.10 Tangible assetsThousands o
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8.1.5.14 Deferred charges & accrued
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8.1.5.18 Finance lease obligations
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Business combination Cellerix SADes
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Weighted averageexercise priceTOTAL
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Page 208 and 209: Additional statementsThe preparatio
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Page 218 and 219: future against which they may be ap
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Page 224 and 225: Thousands of Euro (€)Laboratoryeq
Page 226 and 227: Current financial assetsShown below
Page 228 and 229: At December 31, Cellerix’ share c
Page 230 and 231: 9.1.5.17 Deferred revenueThe balanc
Page 232 and 233: 9.1.5.21 Share-based paymentsThe EB
Page 234 and 235: GrantsCellerix received several gra
Page 236 and 237: 10. Report regarding unaudited prof
Page 238 and 239: EMAFDAFibrous tissueGCPGMPGrowth fa
Page 240 and 241: Appendix 1: Press releases 2006-201
Page 242 and 243: Appendix 2: REGULATORY APPROVALPROC
Page 244 and 245: like ChondroCelect or the future ce
Page 246 and 247: TitleCountry/regionPatent/applicati
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Page 252 and 253: D. Trademarks of CellerixThe table
Page 254 and 255: Decision resources.Dell’Accio, F.
Page 256 and 257: Noyes, F. R., Barber-Westin, S. D.,
Page 258 and 259: Appendix 5: 2008, 2009 and2010 mana
Page 260 and 261: Contents1. The year in brief ......
Page 262 and 263: 2. Financial informationa. The Inco
Page 264 and 265: The Directors shall call a Sharehol
Page 266 and 267: • Exercise price changed to 5.291
Page 268 and 269: 10 • TiGenix • Rights Offering
Page 274 and 275: Exceptionally, for the following re
Page 276 and 277: (d)(e)Duration: The Options Plan wi
Page 282 and 283: eceipt sent to the number or addres
Page 284 and 285: THE COMPANYTiGenix NVRomeinse straa
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ANNUAL FINANCIAL REPORT 2010 2010 - TiGenix

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