• of which the voting right was suspended by a competentcourt or the FSMA.Generally, the shareholders’ meeting has sole authority withrespect to:• the approval of the annual accounts of the Company;• the appointment and resignation of directors and thestatutory auditor of the Company;• the granting of discharge of liability to the directors and thestatutory auditor;• the determination of the remuneration of the directors andof the statutory auditor for the exercise of their mandate;• the distribution of profits (it being understood that theArticles of Association authorise the Board of Directors todistribute interim dividends);• the filing of a claim for liability against directors;• the decisions relating to the dissolution, merger and certainother re-organisations of the Company; and• the approval of amendments to the Articles of Association.4.5 Warrantsto the Company, including but not limited to the membersof the scientific advisory board and the clinical advisors. Thewarrants have been granted free of charge. Each warrantentitles its holder to subscribe to one common share of theCompany at a subscription price determined by the Boardof Directors, within the limits decided upon at the occasionof their issuance. The warrants issued on May 14, 2004,April 20, 2005 and November 3, 2005 had a term of 5 years,but their term was extended until May 13, 2014 by decision ofthe extraordinary shareholders’ meeting held May 13, 2009.The warrants issued on February 26, 2007, March 20, 2008,June 19, 2009 and March 12, <strong>2010</strong> have a term of 10 years. Uponexpiration of this term, the warrants become null and void. Inprinciple, the warrants vest in cumulative tranches of 25% peryear, i.e., 25% as of the first anniversary date of their granting,50% as of the second anniversary date of their granting, 75% asof the third anniversary date of their granting, 100% as of thefourth anniversary date of thwweir granting provided that thecooperation between the Company and the warrant holderhas not yet ended, unless the Board of Directors approved adeviation from this vesting scheme. The warrants can only beexercised by the warrant holder if they have effectively vested.The table below gives an overview (as at March 31, 2011) of the1,755,958 outstanding warrants described above. The tableshould be read together with the notes referred to below.The Company has created a number of warrants. This sectionprovides an overview of the outstanding warrants as at March31, 2011.On May 14, 2004 (135,802), April 20, 2005 (45,268),November 3, 2005 (454,570), February 26, 2007 (800,000),March 20, 2008 (400,000), June 19, 2009 (500,000),March 12, <strong>2010</strong> (500,000) in the aggregate 2,835,640 warrantswere issued, subject to the warrants being granted to andaccepted by the beneficiaries. Of these 2,835,640 warrants,(i) 545,683 warrants expired as they have not been granted,(ii) 327,250 warrants have expired as they have not beenaccepted by their beneficiaries (iii) 197,459 have lapsed due totheir beneficiaries leaving the Company and (iv) 9,290 warrantshave been exercised. As a result, as at March 31, 2011, there are1,755,958 warrants outstanding.The warrants are granted to employees, consultants or directorsof the Company, as well as to other persons who in the scopeof their professional activity have made themselves useful81 •
Issue dateMay 14,2004April 20,2005TermNumber ofwarrantsissued≤ (1)Number ofwarrantsgrantedExerciseprice (€)From May 14, 135,802 133,684 €3.00May 13, 2014 (1) May 23, 2005 grants)2004 to(May 14, 2004 and€3.50(December 9,2005 grant)From April 20, 45,268 45,268 €3.00May 13, 2014 (1)2005 to(May 23, 2005 grant)€3.50(February 6, 2006 grant)Number ofwarrantsno longerexercisableNumber ofwarrantsoutstandingExerciseperiods vestedwarrants (2) (3)24,248 (2) 104,764 (3) From March 16 to 31,and from September15 to 30. (7)/ 45,268 From March 1 to 31,and from September1 to 30.November3, 2005February26, 2007March 20,2008From November3, 2005 to May 13,2014 (1) 454,570 301,805 €3.50(February 6, 2006, March24, 2006, May 2, 2006,July 3, 2006 and August24, 2006 grants)From February 26,2007 toFebruary 25, 2017From March 20,2008 toMarch 19, 2018800,000 681,500 €6.75 (March 24,2007 grant)€5.23 (September 17,2007 grant)400,000 400,000 €4.05 for employeesand €4.41 for otherindividuals (March 20,2008 grant)€4.84 (June 27,2008 grant)160,907 (4) 293,663 From March 1 to 31,and from September1 to 30.289,187 (5) 509,813 From May 1 to 31,and from November1 to 30.102,125 (6) 296,625 From May 1 to 31,and from November1 to 30.€3.48 (September 15,2008 grant)500,000 232,200 €3.95 (June 26,2009 grant)June 19,2009March 12,<strong>2010</strong>From June 19,2009 to June 18,2019From March 12,<strong>2010</strong> toMarch 11, 2020500,000 495,500 €3.62(March 12, <strong>2010</strong> grant)€1.65 for employeesand €1.83 for otherindividuals (July 7,<strong>2010</strong> grant)344,800 (7) 153,325 From May 1 to 31,and from November1 to 30.147,500 (8) 352,500 From May 1 to 31,and from November1 to 30.€1.93 (August 24, <strong>2010</strong>)Notes(1) The extraordinary shareholders’ meeting of May 13, 2005 extendedthe exercise period until May 13, 2014.(2) 2,118 warrants have expired as they have not been granted and22,130 warrants have lapsed due to their beneficiary leaving the Company.(3) 6,790 warrants have been exercised and are therefore no longer outstanding.(4) 152,765 warrants have expired as they have not been granted and8,142 warrants have lapsed due to their beneficiary leaving the Company.(5) 118,500 warrants have expired as they have not been granted;103,750 warrants have expired as they have not been accepted by theirbeneficiary and 67,937 warrants have lapsed due to their beneficiary leavingthe Company.(6) 38,000 warrants have expired as they have not been accepted by theirbeneficiary and 62,875 warrants have lapsed due to their beneficiary leavingthe Company. 2,500 warrants have been exercised and are therefore nolonger outstanding.(7) 267,800 warrants have expired as they have not been granted;62,000 warrants have expired as they have not been accepted by theirbeneficiary and 16,875 warrants have lapsed due to their beneficiariesleaving the Company.(8) 4,500 warrants have expired as they have not been granted; 123,500 warrantshave expired as they have not been accepted by their beneficiary and19,500 warrants have lapsed due to their beneficiary leaving the Company.On March 31, 2011, the total number of all outstanding warrantsthat have already been granted, is 1,755,958, which representsapproximately 2.24% of the total number of all issued andoutstanding voting financial instruments, as shown insection 4.6.82 • <strong>TiGenix</strong> • Rights Offering
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TiGenix NV(Public limited liability
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Table of ContentsSummary ..........
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3.7.1 Categories of potential inves
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5.7.1 Shares and warrants held by i
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7.5.2 Taxation.....................
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SummaryThe words written in capital
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Activities and strategy of the Comp
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• Two allogeneic adult stem cell
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• TiGenix’ success depends on i
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Unaudited pro forma income statemen
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Recent developmentsAcquisition of C
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In this context, we would like to s
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Announcement of the results of theO
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After the Contribution andafter the
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ContributionContribution AgreementC
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Risk factorsAny investment in the P
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commercialisation of ChondroCelect,
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in delays in bringing products to t
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The Company cannot predict what eff
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in Cellerix’ GMP facility in Madr
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6.14.3 History and development of C
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The table below gives an overview o
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Prevalence No. of cases (2010) Esti
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Fig. 6.9: Platform development stra
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In developing Cx601, Cellerix has b
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6.14.6 Manufacturing & logisticsCel
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population, methods for the isolati
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• Cimzia (certolizumab) - UCB: Al
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Spanish Ministry of Education and S
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7.2 Consolidated income statementTw
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7.3.1.2 Research and development ex
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7.3.2.3 Selling, general and admini
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Cash & cash equivalents and intangi
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As of December 31, 2010, the Group
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8. Consolidated Financial informati
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8.1.5 Notes to consolidated financi
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operating results and operating pla
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The Group does not account for work
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8.1.5.4 Operating result (EBIT)Resu
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8.1.5.7 TaxesThere is no current ta
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8.1.5.10 Tangible assetsThousands o
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8.1.5.14 Deferred charges & accrued
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8.1.5.18 Finance lease obligations
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Business combination Cellerix SADes
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Weighted averageexercise priceTOTAL
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the respective issue date of the wa
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Transactions with non-executive dir
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8.1.5.28 Subsequent eventsAcquisiti
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8.1.5.31 Disclosure under Article 1
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Additional statementsThe preparatio
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9.1.2 Stand-alone balance sheetYear
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9.1.4 Stand-alone statement of chan
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) Standards and interpretations iss
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The clinical development of new dru
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future against which they may be ap
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Cellerix’ research and developmen
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YearThousandsof Euro2010 2009 2008E
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Thousands of Euro (€)Laboratoryeq
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Current financial assetsShown below
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At December 31, Cellerix’ share c
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9.1.5.17 Deferred revenueThe balanc
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9.1.5.21 Share-based paymentsThe EB
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GrantsCellerix received several gra
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10. Report regarding unaudited prof
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EMAFDAFibrous tissueGCPGMPGrowth fa
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Appendix 1: Press releases 2006-201
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Appendix 2: REGULATORY APPROVALPROC
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like ChondroCelect or the future ce
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TitleCountry/regionPatent/applicati
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TitleCountry/regionPatent/applicati
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Title“Cell populations having imu
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D. Trademarks of CellerixThe table
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Decision resources.Dell’Accio, F.
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Noyes, F. R., Barber-Westin, S. D.,
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Appendix 5: 2008, 2009 and2010 mana
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Contents1. The year in brief ......
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2. Financial informationa. The Inco
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The Directors shall call a Sharehol
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• Exercise price changed to 5.291
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10 • TiGenix • Rights Offering
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Contents1. The year in brief ......
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3. Financial informationa. The Inco
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Exceptionally, for the following re
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(d)(e)Duration: The Options Plan wi
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Contents1. The year in brief ......
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3. Financial informationa. The Inco
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eceipt sent to the number or addres
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THE COMPANYTiGenix NVRomeinse straa