ANNUAL FINANCIAL REPORT 2010 2010 - TiGenix

Decision resources.Dell’Accio, F., De Bari, C., and Luyten, F. P. (2001) Molecular markers predictive of the capacity of expanded human articularchondrocytes to form stable cartilage in vivo. Arthritis Rheum. 44: 1608-1619Dell’Accio, F., Vanlauwe, J., Bellemans, J., Neys, J., De Bari, C., and Luyten, F. P. (2003) Expanded phenotypically stable chondrocytespersist in the repair tissue and contribute to cartilage matrix formation and structural integration in a goat model of autologouschondrocyte implantation. J.Orthop.Res. 21: 123-131Englund M., (2004) Meniscal tear--a feature of osteoarthritis, Acta Orthop Scand Suppl. Apr;75(312):1-45.FDA (1998) Guidance for industry. Guidance for human somatic cell therapy and gene therapy. FDAFrosch KH, Fuchs M, Losch A, Stürmer KM., (2005) Repair of meniscal tears with the absorbable Clearfix screw: results after 1-3 years,Arch Orthop Trauma Surg. ov;125(9):585-91.Gabriel, S. E. & Michaud, K., Arthritis Res. Ther, 11(3), p.229, 2009Gelber, A. C., Hochberg, M. C., Mead, L. A., Wang, N. Y., Wigley, F. M., and Klag, M. J. (5-9-2000) Joint injury in young adults and risk forsubsequent knee and hip osteoarthritis. Ann.Intern.Med. 133: 321-328Getgood A. et al., Poster, British Association for Repair of the Knee, Edinburgh, April 2009Getgood A. et al., “Evaluation of Early-Stage Osteochondral Defect Repair Using a Biphasic Scaffold based on a Collagen-Glycosaminoglycan Biopolymer in a Caprine Model”. The Knee, Accepted, In PressGikas, P. D., Morris, T., Carrington, R., Skinner, J., Bentley, G., and Briggs, T. (2009) A correlation between the timing of biopsy afterautologous chondrocyte implantation and the histological appearance. J Bone Joint Surg.Br. 91: 1172-1177Gill T, Asnis P, and Berkson E (2006) The treatment of articular cartilage defects using the MF technique. J Orthop Sports Phys Ther 36:728-738Gill, T. J. and Steadman, J. R. (2004) Bone marrow stimulation techniques: microfracture, drilling and abrasion. Articular cartilage lesions: apractical guide to assessment and treatment 63-72Grande, D. A., Pitman, M. I., Peterson, L., Menche, D., Klein, M. (1989), The repair of experimentally produced defects in rabbit articularcartilage by ACT. J Orthoped Res 208-218Halme, D. G. and Kessler, D. A. (19-10-2006) FDA regulation of stem-cell-based therapies. N.Engl.J.Med. 355: 1730-1735Hangody, L. and Fules, P. (2003) Autologous osteochondral mosaicplasty for the treatment of full-thickness defects of weight-bearingjoints: ten years of experimental and clinical experience. J.Bone Joint Surg.Am. 85-A Suppl 2: 25-32Harley, B. A., Lynn, A. K., Wissner-Gross, Z., Bonfield, W., Yannas, I. V., Gibson, L. J., (2010) Design of a multiphase osteochondral scaffold. IIFabrication of a mineralized collagen-glycosaminoglycan scaffold. J Biomed Mater Res A, Mar 1;92(3):1066-77Harley, B. A., Lynn, A. K., Wissner-Gross, Z., Bonfield, W., Yannas, I. V., Gibson, L. J., (2010) Design of a multiphase osteochondral scaffold. IIIFabrication of layered scaffolds with continuous interfaces. J Biomed Mater Res A, Mar 1;92(3):1078-93Haute Autorité de Santé (2005) Evaluation de la greffe chondrocytaire autologue du genou - Rapport d’étape. HASHelmic,C et all. Estimates of the Prevalence of Arthritis and Other Rheumatic conditions in the US, Arthritis & Rheumastism 58(1), 15-25.2008.Hjelle, K., Solheim, E., Strand, T., Muri, R., and Brittberg, M. (2002) Articular cartilage defects in 1,000 knee arthroscopies. Arthroscopy 18:730-734Hoser C, Fink C, Brown C, Reichkendler M, Hackl W, Bartlett J.,(2001) Long-term results of arthroscopic partial lateral meniscectomy inknees without associated damage, J Bone Joint Surg Br. May;83(4):513-6.243 •