Physiological Pharmaceutics

Chapter SixDrug Absorption from the Small IntestineANATOMY AND PHYSIOLOGY OF THE SMALL INTESTINEGross morphologyMucosaOrganisation of the mucosaFolds of KerckringVilliMicrovilliEpitheliumCrypts of LieberkühnThe gastrointestinal circulationThe lymphatic systemStructure of the lymphaticsFormation of lymphComposition of lymphStimulation of lymphatic transportSecretions into the small intestineGlandsPancreatic secretionBiliary secretionSecretion and absorption of waterDigestion and absorption of nutrientsCarbohydratesProteinsFatsIronPATTERNS OF MOTILITY IN THE SMALL INTESTINEStagnation at the ileocaecal junctionSMALL INTESTINAL TRANSIT TIMESMethods for measuring small intestinal transitSmall intestinal transit times of foodPhysiological and pathophysiological effects on small bowel transitSmall intestinal transit time of dosage formsDensity and small intestinal transitABSORPTION OF DRUGSAbsorption and delivery of macromoleculesIntestinal pHSolvent drag and intestinal permeabilityP-glycoproteinCytochrome P450 3A4 (CYP3A4).Intestinal reserve lengthInteraction with foodVitamin effectsSalt effects109