Physiological Pharmaceutics

Chapter ThreeDrug Delivery to the Oral Cavityor MouthANATOMY AND PHYSIOLOGYThe oral cavityThe palateThe tongueThe teethOrganisation of the oral mucosaFunctions of the oral mucosaSalivary secretionSalivary glandsSalivaMIGRATION AND CLEARANCE OF SUBSTANCES FROM THE ORAL CAVITYABSORPTION OF DRUGS ACROSS THE ORAL MUCOSADisadvantages of oral mucosal deliveryEffect of position on drug deliveryGingival penetrationImproving penetration through the mucosaMEASUREMENT OF ORAL MUCOSAL DRUG ABSORPTIONDOSAGE FORMS FOR THE ORAL CAVITYChewable formulationsFast-dissolving dosage formsBioadhesive dosage formsDental systemsDRUGS ADMINISTERED VIA THE ORAL MUCOSANitratesSteroidsAnalgesicsAntibioticsAntifungalsOthersCONCLUSIONSREFERENCES37