Physiological Pharmaceutics

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Index 305Indomethacin 165, 172Infertility 209Inflammatory bowel disease 163, 173Inhaled particles 203Inhaler technique 241Insulin 33, 194, 213, 245, 277, 280Integument 182Interferon 194Intestinal cells 116Obstruction 123Reserve length 132Intestinal juicepH 116Intra-ocular injection 262Intramuscular delivery 26Pharmacokinetics 26IntranasalDrugs 208Intraocular devices 268drug delivery 266Intrauterine devices 279Intravaginal inserts 278Intravenous delivery 20, 21Intrinsic factor of castle 79, 82, 112Inulin 260Iodides 277Ion exchange resins 101Iontophoresis 190, 192Eye 268Ipratropium bromide 209, 244Iris 256Iron 120, 134Isomaltase 119Isoprenaline 122Ispaghula 155IUDs. See also intrauterine devicesJJejunum 110Blood supply 113Jet nebulizer 235KK99-fimbrial proteins 129Kanamycin 245Kartegener’s syndrome 205Keratinocytes 183, 187Kerkring’s folds 118Ketobemidone 48Kupffer cells, 24LL-tryptophan 90Labrafil WL2514 168Lacrimal drainage system 255Lacrimal glands 202, 255Lacrimal puncta 255Lactase 119Lactate dehydrogenase 202, 276Lacteals 114Lactic acid 150, 275Lactic dehydrogenase 202Lactobacillus 150Lactobacillus acidophilus 275Lactose 66, 119Lactulose 150Lamina cribrosa 252Lamina propria 39, 60, 110Langerhans cells 183, 187Langmuir trough 2Lanolin 264Lanthanum 46Large intestine. See colonLaryngectomies 206Larynx 222Lateral diffusion 4Laureth-9 210LCFA. See long-chain fatty acidsLecithins 172, 230, 232Lectins 128, 163Leucine animopeptidase 202Leucotrienes 208Leukotriene inhibitors 244Levonorgestrel 278Lidocaine 52, 191Limbus 251Lipases 82, 120, 151Lipids 7, 46Liposomes 4, 6, 7, 29, 33, 191Eye 267Lithium 126Liver 20, 116Locust bean gum 164Long-chain fatty acids 156Loperamide 156Lorazepam 55Lotions 189Lower oesophageal sphincter 92Loxiglumide 157Lozenge 49LTE4 244LungAnatomy and physiology 222Biochemical processes 230Blood supply 229Defenses 228Deposition 241Disease 230Dosage forms 232Drugs 243Drug absorption 242
306 IndexEpithelium 225Factors affecting deposition 239Humidity 240Lymphatic system 229Mucus 227Nervous control 229Particle size 240Permeability 227Radiolabelling formulations 238Surfactant 228Lycopersicon esculentum 163Lymph 21Composition 115Ducts 273Formation 115Lung 229Stimulation of transport 115Lymphatic system 21, 114Drug absorption 136Nose 202Structure 114Lymphocytes 110, 115Lymphoglandular complexes 147Lypressin 209Lysine 119Lysosomal proteinases 202Lysozyme 113, 202, 258MM-cells 114, 129Macrophages 146Magnesium 134Magnetic dose forms 100Malic enzymes 202Maltase 119Maltose 119Maltotriose 119Marshmallows 63Mast cells 7, 110, 184, 244Matrix-diffusion controlled system 189MDR See multi-drug resistanceMedoxyprogesterone acetate 278Meibomian glands 255Meissner plexus 61, 148Membrane asymmetry 7coating-granules 46proteins 7permeation controlled system 189Menopause 275, 277Menstrual cycle 207, 274, 275, 276, 278Menthol 164Mercaptans 153Mesalazine 163, 173Mesenteric veins 147Met-enkephalin 153MetabolismGut wall 147Metaproterenol 243Metered dose inhalers 232Methacrylate copolymer 66Methadone 171Methane 150Methohexital 170Methotrexate 22, 29Methylcellulose 212, 263Methylene blue 277Methylmethacrylate 163Methylmorphine 32Methylxanthines 244Metoclopramide 172Metronidazole 53, 55, 133, 172Micelles 3Microfold cells See M-cellsMicroneedles 190MicroparticulatesEye 267Micropor 190Microsealed system 189Microspheres 213Microvilli 111, 112, 118Midazolam 170, 210Migraine 93, 245Migrating motor complex See Migratingmyoelectric complexMigrating myoelectric complex 85, 117,122, 124Milk 133Mist-assist ® 234Mistabron ® 245Mitomycin 22Monkey 216Monozygotic twins 204Montelukast sodium 244Morphine 32, 54, 156, 165, 171Motilin 113MotilityColon 151, 153Gastric 85Oesophageal 61Small intestine 120Mouse 216Mucins 147Muco-ciliary escalator 228Mucoadhesion See also bioadhesion 18, 99Oral tablet 52Patches 48Mucociliary clearance 203, 204Mucoid cells 79Mucolytics 244Mucopolysaccharides 260Mucostasis 207Mucus 17, 96, 147, 202, 227, 276Lung 227
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For Alexander and SarinaWith all ou
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First edition 1989Second edition fi
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viPrefacepublishers, who I am sure,
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viiiAcknowledgementsFig 6.5 is repr
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Table of Contents1. Cell Membranes,
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xiiContentsGASTRIC pH .............
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xivContents9. Nasal Drug Delivery .
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Chapter OneCell Membranes, Epitheli
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Membranes and barriers 3Figure 1.1
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Membranes and barriers 5Modulation
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Membranes and barriers 7Membrane pr
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Chapter TwoParenteral Drug Delivery
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Parenteral drug delivery 21Figure 2
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Parenteral drug delivery 23catheter
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Parenteral drug delivery 29fluid is
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Parenteral drug delivery 33Receptor
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Parenteral drug delivery 3526. Tsuj
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38 Physiological PharmaceuticsANATO
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58 Physiological Pharmaceutics59. A
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60 Physiological PharmaceuticsINTRO
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72 Physiological Pharmaceutics12. W
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Chapter FiveThe StomachANATOMY AND
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The stomach 77Figure 5.2 Structure
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The stomach 79Gastric glandsThe gas
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The stomach 81Figure 5.7 Mechanism
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The stomach 83absorbed from the sto
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The stomach 85Night-time transient
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The stomach 87particle size indiges
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The stomach 89Figure 5.13 MRI cross
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The stomach 91species and man is po
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The stomach 93Figure 5.15 The effec
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The stomach 95emerged from the shel
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The stomach 97Figure 5.17 The gastr
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The stomach 99In order to improve b
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The stomach 101Figure 5.21—Gastri
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The stomach 103The anatomy and dime
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The stomach 10533:1283-1290.35. Cun
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The stomach 10782. Ingani HM, Timme
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Chapter SixDrug Absorption from the
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Small intestine 111Figure 6.1 Secti
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Small intestine 113are uncommon and
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Small intestine 115underlying tissu
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Small intestine 117Brief periodic b
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Small intestine 119is extremely rap
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Small intestine 121Figure 6.5 Segme
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Small intestine 123Measurements of
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Small intestine 125Figure 6.8 Small
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Small intestine 127Scintigraphy oft
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Small intestine 129It is known that
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Small intestine 131It was soon real
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Small intestine 133colonic absorpti
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Small intestine 135also transform d
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Small intestine 137REFERENCES1. Bry
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Small intestine 13949. Hidalgo IJ,
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Small intestine 14193. Bogentoft C,
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Chapter ElevenOcular Drug DeliveryI
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Ocular drug delivery 251STRUCTURE O
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Page 276 and 277: Ocular drug delivery 259Figure 11.9
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Page 282 and 283: Ocular drug delivery 265endothelial
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Page 288 and 289: Chapter TwelveVaginal and Intrauter
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Page 301 and 302: 284 GlossaryAntipyrine An analgesic
Page 303 and 304: 286 GlossaryClonazepam An anticonvu
Page 305 and 306: 288 GlossaryEsterase An enzyme whic
Page 307 and 308: 290 Glossaryfound in the synovial f
Page 309 and 310: 294 GlossaryPectoral muscle Chest m
Page 311 and 312: 296 Glossarysize exclusion (gel fil
Page 313 and 314: 298 GlossaryTributyrase An enzyme w
Page 315 and 316: 300 Indexß-glucuronidase 276B cell
Page 317 and 318: 302 IndexDiazoxide 262Dichlorodiphe
Page 319: 304 IndexGelling polymers 264Gels 1
Page 323 and 324: 308 IndexOros ® 158Osmotic deliver
Page 325 and 326: 310 IndexAbsorption 186Age 188Disea
Page 327: 312 IndexDrug absorption 277Fluid 2
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Physiological Pharmaceutics

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