Physiological Pharmaceutics

Index 301Cholecystokinin 113, 148, 152Cholera 117Cholesterol 46, 112, 115, 183Bile salts 116Cholinergic agonists 102, 214Chondroitin 263Choroid plexi 32, 252Chronic alcoholism 70Chylomicrons 115, 120Chyme 117, 118, 122Chymotrypsin 119Cigarette smoking 206, 231, 242Ciliogenesis 276Cilioinhibition 213Ciliotoxicity 213Cimetidine 130, 133Cinnarizine 100Citrate 50Clara cells 225Clonazepam 169Clonidine 187Codeine 32, 135, 156, 172, 173Coffee 156Collagen 7, 184, 252Shields 266Colloidal delivery 33ColonAnatomy and physiology 144Bacteria 147, 150Blood supply 147Drug absorption 157Co-medication 165Disease 165Drug delivery 157Electrical activity 152Environment 149Humoral control 148Interspecies variation 145Motility 151, 153Mucosa 146Nervous and control 148Particle size 159pH 150Structure 146Targeting 161, 162, 163Temporal factors 161Transit of dose forms 156, 158Transit time 154Water and electrolytes 149Columnar cells 8Columnar epithelium 8, 111Upper airway 225Conjunctiva 252Drug penetration 259Conjunctival fornix 255Connective tissue 39Constipation 92Contraceptive pill 134Copper 279Cornea 251, 252, 257Corneocyte 183Corticosteroids See also Steroids 53, 173Cotransport 14Cotton pledgets 63Cough 229Creams 48, 189, 278Crohn’s disease 147, 165Crypt cells 117Crypts of Lieberkühn 16, 113, 146Crystal suspension 27Crytococci 54Cushing’s syndrome 214Cyanoacrylate microspheres 33Cyclacillin 14Cyclic AMP 10Cyclodextrins 164. 187, 192Cyclosporin A 130Cydot 52CYP 3A4 See cytochrome P450:3A4Cysteinyl leukotriene receptors 244Cystic fibrosis 244Cystic fibrosis transmembrane conductanceregulator 117Cytochrome p-450 dependentmonooxygenases 202Cytochrome p450 128 3A4 131, 134Cytoplasm 2Cytosis 15Cytosol 7DDanazol 277DDT. See dichlorodiphenyltrichloroethaneDecongestant sprays 208Decylmethyl sulphoxide 191Defaecation 153Deltoid. See muscleDensity 96, 99Dental systems 53Deoxycorticosterone 53Dermis 182, 184Descemet’s membrane 251, 252Descending colon 145Desmopressin 209, 212Desmosomes 9, 11, 273Dexamethasone 214, 265Dextran 213Hydrogels 162Dextropropoxyphene 135, 173Diabetes insipidus 209Diabetes mellitus 70Diarrhoea 117Diazepam 169, 170, 173