Physiological Pharmaceutics

Index 303Ethylcellulose 262Ethylenediaminepentaacetic acid 48Eudragit 161, 164Exercise 93, 123, 154, 229Exosurf ® 229Explotab ® 66Extravasation 22Eye 250–270Cornea 251Drops 260, 262Drug distribution 259Drug permeation 257Drug retention 260Eyelids 252, 253Gelling polymers 264Instilled volume 261Intraocular devices 268Ionization 257Iontophoresis 268Liposomes 267Microparticulates 267Nanoparticles 267Ointments 264Particulates 265Perfusion 262pH 257Pigmentation 258Precorneal tear film 253Preservatives 261Protein binding 258Sprays 263Structure 251Sustained release devices 265Systemic administration 262, 268Viscosity 263FFacilitated diffusion 14Faraday crispations 235Faspak ® 24Fast-dissolving dosage forms 48, 50, 66Fats 91, 119, 152Fatty acids 48, 183, 191Fenoterol 55, 243Ferrireductase 120FibreDietary 134, 150, 154, 155, 157,161Fibrinogen 274Fibronectin 7, 8Fick’s law 12First-pass metabolism 20, 114, 118, 134,171, 172, 182Rectum 166Fluid mosaic model 2Flumist ® 210Flunisolide 214Fluorescein 256Fluorocarbons 25Folds of kerckring 111FoodAbsorption 82, 118Digestion 82, 118Flavour 39Ingestion 214Mixing 90Formaldehyde 207Foveolae 77Frenulum linguae 38Fundus 76Fungizone 23GGALT See gut-associated lymphoid tissueGamma scintigraphy 50, 52, 94, 127, 213Lungs 237Oesophageal transit 66Ganciclovir 268Gap junctions 9, 10Gastric emptying See also stomach: motilityDisease 93Dosage forms 95, 97Drug-induced effects 102Exercise 93Fat 91Menstrual cycle 92Oils 91Pellets 97Physiological factors 92Posture 101Gastric glands 79Gastric inhibitory peptide 113GastricJuice 80Motility 85Mucus 77Peptides 7Pits 77Secretion 80Gastric emptyingPregnancy 92Gastric pH 83Enteric coatings 102Gastrin 79, 80, 113, 148, 152Gastritis 93Gastro-oesophageal junction 61, 68, 77, 83Gastro-oesophageal reflux 63, 70, 88, 92,93Gastrocolic reflex 152, 161Gelatin cylinders 63Gelatinase 82Gellan gum 264