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Type B insulin resistance Clinical Presentation Severe insulin resistance with acanthosis nigricans (95%) Either fasting or postprandial hypoglycemia Female predominance History of autoimmune disease, Hodgkin's disease Hypoglycemia at low-titer of IR-A
Type B insulin resistance Laboratory Findings Hypoglycemia may be severe(15~30 mg/dL) Insulin levels - inappropriately high C-peptide levels - appropriately low during hypoglycemia Low TG, high adiponectin, polyclonal IgG Elevated variable autoantibodies including antinuclear,antithyroid, antimitochondrial, and antiplatelet antibodies -suggestive of subclinical autoimmune disease The absence of any of these laboratory findings in a patientwith IR-A and hypoglycemia should prompt a search forHodgkin's disease
Page 1 and 2: Autoimmune Hypoglycemia2010. 05. 08
Page 3 and 4: Introduction Hypoglycemia incidence
Page 5 and 6: IntroductionAutoimmune causes Insul
Page 7 and 8: Insulin Autoimmune Syndrome First o
Page 9 and 10: Insulin Autoimmune Syndrome Clinica
Page 11 and 12: Insulin Autoimmune Syndrome Pathoge
Page 13 and 14: Insulin Autoimmune Syndrome Origin
Page 15 and 16: Insulin Autoimmune Syndrome Numerou
Page 17 and 18: Insulin Autoimmune Syndrome Altered
Page 19 and 20: Insulin Autoimmune Syndrome Course
Page 21: Type B insulin resistance In 1975,
Page 25 and 26: IR-AType B insulin resistance Polyc
Page 27 and 28: Type B insulin resistance Diagnosis
Page 29 and 30: Type B insulin resistance Course an
Page 31: Summary
Page 34: 감 사 합 니 다A
Page 38 and 39: Insulin Autoimmune Syndrome Laborat
Page 40 and 41: Interpretation of values after 72 h
Page 42 and 43: Target autoantigens in type 1 diabe
Page 44: Introduction IA have also been demo

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