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Microsoft PowerPoint - S14-1_\300\374\274\272\277\317 [\310\243 ...
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Target autoantigens in type 1 diabetes mellitusGlutamic acid decarboxylase (GAD)Insulin autoantibody (IAA)Insulinoma –associated protein 2 (IA-2)Carboxypeptidase H, PM-1 polar antigenIslet cell proteins of varying size and unknown function - 37 or 40 kD, 38 kD, 52 kD, 69 kDPeripherinHeat shock protein 65Insulin receptorEndocrine cell antigensCytoskeletal proteins - tubulin, actin, reticulinNuclear antigens - single-stranded DNA and RNAAutoantibody :GADA (antibody to glutamic acid decarboxylase)--- β-cell destruction early markerICA (islet cell autoantibody)—specificity lowIAA (autoantibody to insulin) —specificity lowIA-2 ( autoantibody to tyrosine phosphatases IA-2 andIA-2β)---specificity high