Microsoft PowerPoint - S14-1_\300\374\274\272\277\317 [\310\243 ...

IR-AType B insulin resistance Polyclonal IgGs, which may becomposed of varioussubpopulation of immunoglobulinswith varying agonist or antagonistactivity toward the insulin receptor In support of this hypothesis, Sestiand co-workers demonstrated thattwo IgG subfractions from apatient with IR-A andhypoglycemia differed in theirability to inhibit insulin binding tothe two distinct human insulinreceptor subtypesSesti G, Diabetes. 1992