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Insulin Autoimmune Syndrome In 1970, Hirata described a patientwith severe hypoglycemia with presence of IA Hirata suggested the term autoimmune insulin syndrome todescribe a syndrome of hypoglycemia elevated insulin levels high levels of IA without previous exposure to exogenousinsulinHirata Y, J Soc Diabetes Cos. 1970 Over 300 cases of IA-associated hypoglycemia have beenreported since 1970, with 80% of cases reported in Japan