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Target autoantigens in type 1 diabetes mellitus Insulin auto antibody (IAA) The early appearance of anti-insulin antibodies suggests that insulinis an important autoantigen Confirmed at 1993, from studies in NOD mice Glutamic acid decarboxylase (GAD) found in about 70 percent of patients with type 1 diabetes at the timeof diagnosis Insulinoma-associated protein 2 (IA-2) neuroendocrine protein called insulinoma-associated protein 2, whichis a protein tyrosine phosphatase 58 percent of patients with type 1 diabetes at the time of diagnosis usually appear later than IAA and GAD, and are highly associatedwith expression of multiple anti-islet autoantibodies and progressionto diabetes
Type 1 DM PathogenesisHLA-DR/DQGenetic susceptibilityEnviromental factors initiate(Virus infection, chemical, diet)GADA,IAA,ICAIA2 andIA-2βautoimmuneidiopathyβ-cell destructionAbsolute insulin deficiency(ID)(Low C-peptide level)Prone to ketoacidosis
Page 1 and 2: Autoimmune Hypoglycemia2010. 05. 08
Page 3 and 4: Introduction Hypoglycemia incidence
Page 5 and 6: IntroductionAutoimmune causes Insul
Page 7 and 8: Insulin Autoimmune Syndrome First o
Page 9 and 10: Insulin Autoimmune Syndrome Clinica
Page 11 and 12: Insulin Autoimmune Syndrome Pathoge
Page 13 and 14: Insulin Autoimmune Syndrome Origin
Page 15 and 16: Insulin Autoimmune Syndrome Numerou
Page 17 and 18: Insulin Autoimmune Syndrome Altered
Page 19 and 20: Insulin Autoimmune Syndrome Course
Page 21 and 22: Type B insulin resistance In 1975,
Page 23 and 24: Type B insulin resistance Laborator
Page 25 and 26: IR-AType B insulin resistance Polyc
Page 27 and 28: Type B insulin resistance Diagnosis
Page 29 and 30: Type B insulin resistance Course an
Page 31: Summary
Page 34: 감 사 합 니 다A
Page 38 and 39: Insulin Autoimmune Syndrome Laborat
Page 40 and 41: Interpretation of values after 72 h
Page 44: Introduction IA have also been demo

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