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Introduction IA have also been demonstrated with lispro insulin therapy andin women receiving short-term human insulin therapy forgestational diabetes IA induced in response to insulin therapy are typicallypolyclonal IgGs with two classes of binding sites sites with high affinity/low capacity (Ka 10 7 M -1 , b10 -9 M) sites with low affinity/high capacity (Ka 10 7 M -1 , b10 -7 M)