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Insulin Autoimmune Syndrome First observation of IA and hypoglycemia A 34-year-old T1D woman with intermittent episodes ofsevere hypoglycemia The patient's serum contained IA with high insulin bindingcapacity and a slow rate of dissociation of insulin-antibodycomplexes It was postulated that insulin was "stored" at high levels inthe serum bound to IA, and that the slow rate of dissociationof insulin from the IA complex resulted in intermittenthypoglycemiaHARWOOD R. N Engl J Med. 1960