ANNUAL REPORT Kunming Institute of Botany, Chinese Academy ...

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Kunming Institute of Botany, Chinese Academy of SciencesAnnual ReportA Series of Platinum Complexes Exhibit SelectiveCytotoxicity towards Cancer CellsPlatinum-based drugs have become fundamentalcomponents of standard chemotherapy regiments,and are widely used in antitumor therapy of testicularand ovarian tumors, lung and colorectal carcinomas.Despite the therapeutic benefit, the efficacy ofplatinum-based treatment regiments is considerablycompromised not only by severe side-effects but alsoby insurmountable cross-resistance.With coorperation between Prof. LIU Wei-Ping'sgroup in Kunming Institute of Precious Metals, andProf. LI Yan's group in KIB, a series of platinum (II)complexes were designed and synthesized featuringa dichloroactetate moiety tethered to the leavinggroup via ester bond, Among of which, mixed-NH3/cyclopentamine platinum(II) complexes of3-dichoroacetoxylcyclobutane-1,1-dicarboxylateexhibit selective cytotoxicity towards cancer cellsthrough inducing the apoptosis of cancer cells,whereas leaving the normal cells much less affected.Also, the complexes are able to overcome theresistance of cancer cells to cisplatin, which show apromising value for further exploration. The patenton the structures and activities has been authorized(ZL20101027465.2).The structures of synthesized complexesTable1. selective cytotoxicity of synthesized complexes towards cancer cells [a]IC50 (μM)complexSK-OV-3 SGC-7901 22RV-1 A549 Beas-2BSIKK-01 46.7 56.1 58.9 61.8 79.9 1.29KK-04 43.3 31.4 25.9 50.9 59.8 1.17KK-05 18.8 22.1 17.1 17.1 60.1 3.51KK-06 10.6 16.8 18.2 15.2 52.3 3.44Cisplatin 7.15 13.7 13.2 14.8 11.6 0.78Carboplatin 100 127 64.8 140 73.7 0.52 —— HIGHLIGHTS OF ACHIEVEMENTS ——
Kunming Institute of Botany, Chinese Academy of SciencesAnnual ReportHorizontal Gene Transfer (HGT) might have HelpedPlants to Colonized the LandThe conquest of land by plants is one of themost important events in life history on earth.Accompanied by the water-to-land transition,the early land plants evolved series of physicaland physiological innovations to adapt to hostileterrestrial environments such as intense UV radiation,gravity, flooding and desiccation cycles and varyingtemperatures. A recent study revealed that foreigngenes horizontally transferred from other kingdomsof life might have facilitated plants to colonize theland.Conducted by groups of Prof. SUN Hang,Prof. YANG Yong-Ping, Prof. HU Xiang-Yang fromKIB, and group of Prof. HUANG Jin-Ling fromEast Carolina University of USA, and financiallysupported by the CAS/SAFEA InternationalPartnership Program for Creative Research Teamsand a US NSF grant, this study thoroughly analyzedthe genome of Physcomitrella patens, a mossrepresenting a basal lineage of land plants, and foundthat 128 nuclear genes from 57 families of mossgenome were originated from fungi, bacteria, andviruses. Further gene annotation analyses revealedthat most of these acquired genes are involved insome essential or plant-specific activities such asxylem formation, plant defense, nitrogen recyclingas well as the biosynthesis of starch, polyamines,hormones and glutathione. Acquisition of thesegenes might have helped the transition of plants fromaquatic to terrestrial environments, and thus haveprofound influence in the land plants evolution.For the first time, this study revealed theexistence of large number of HGT genes in plantgenome, which challenged the conventional beliefthat HGT in multicellular eukaryotes is rare andinsignificant. Therefore, this study provides newinsights for people to reconsider the role of HGT inthe evolution of multicellular eukaryotes. The resultwas reported in Nature Communications ( 2012,3(1152: 1-9).A hypothetical scheme of HGT in mossesDiagram illustrating the dynamics of HGT in plants—— HIGHLIGHTS OF ACHIEVEMENTS ——
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ANNUAL REPORT Kunming Institute of Botany, Chinese Academy ...

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