100% Positive Material Identification
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Dental Implants<br />
(continued from page 52)<br />
Safety Standards<br />
(continued from page 54)<br />
Biocompatibility<br />
(continued from page 27)<br />
promising and provides a basis for exciting<br />
improvements in dental implant design for<br />
patients with compromised bone healing.<br />
However, the body of research to date<br />
has still not clearly identified the optimal<br />
pore size, geometry and graduation for<br />
the most effective biomechanical and<br />
biological properties. Therefore, further<br />
studies are necessary to evaluate the<br />
potential of advanced manufacturing<br />
methods to optimize the porous titanium<br />
structure of dental implants. •<br />
Acknowledgments<br />
The authors acknowledge funding for ZJW<br />
from Iraqi Ministry of Higher Education<br />
and Scientific Research and or WvG from<br />
Orthopaedic Research UK (ORUK). The<br />
views expressed here do not necessarily<br />
represent those of ORUK.<br />
Information on the authors:<br />
Zena J. Wally 1,2,3,<br />
William van Grunsven 1,2,<br />
Frederik Claeyssens 1,2,3,<br />
Russell Goodall 1<br />
Gwendolen C. Reilly 1,3,*<br />
Department of <strong>Material</strong>s Science and<br />
Engineering, University of Sheffield, Sir<br />
Robert Hadfield Building, Mappin St,<br />
Sheffield S1 3JD, UK; E-Mails: zjwally1@<br />
sheffield.ac.uk (Z.J.W.); w.vangrunsven@<br />
gmail.com (W.G.); f.claeyssens@sheffield.<br />
ac.uk (F.C.); r.goodall@sheffield.ac.uk (R.G.)<br />
(2) Kroto Research Institute, University of<br />
Sheffield, Broad Lane, Sheffield S3 7HQ,<br />
UK<br />
(3) Insigneo Institute for in silico Medicine,<br />
University of Sheffield, Pam Liversidge<br />
Building, Mappin St, Sheffield S1 3JD, UK<br />
Author to whom correspondence should be<br />
addressed:<br />
E-Mail: g.reilly@sheffield.ac.uk<br />
Tel.: +44-0-114-222-5986<br />
Fax: +44-0-114-222-5943<br />
of the existing standards in IATA, DOT,<br />
OSHA, EPA and NFPA for determining<br />
flammability and combustibility of<br />
titanium are acceptable and might<br />
truly reflect what the industry is now<br />
producing and how it is being processed.<br />
“If that is the result, then the ITA Safety<br />
Committee can take the position that<br />
we recognize there have been a lot of<br />
changes in the past 50 years; that the<br />
community has assessed to the best of<br />
its ability that industry is on the proper<br />
course, and the resulting information<br />
will be provided to the ITA membership,”<br />
Lee said. “Conversely, Phase 1 may result<br />
in finding that some testing standards<br />
are incorrect, incomplete or obsolete<br />
and there may need to be a fundamental<br />
examination of what those should be.<br />
After the data and practices are collected<br />
and before any final decisions are<br />
made, ITA will organize a committee of<br />
experts including experts from outside<br />
the industry to conduct an appropriate<br />
peer review to increase the potential for<br />
getting it right.”<br />
This initiative is a continuation of<br />
the Safety Committee’s efforts to bring<br />
awareness to all safety issues when<br />
handling and working with titanium.<br />
Visit the ITA’s website (titanium.org)<br />
for more information on the work of the<br />
Safety Committee. •<br />
ITA 2016 Safety Executive<br />
Committee Members:<br />
Robert Lee, President - Accushape Inc.<br />
(Chair)<br />
Dietmar Fisher, Consultant, Dipl.-Ing. -<br />
Titanium Consultancy & Training<br />
Kevin Kreitman, Safety Consultant -<br />
Retired Redding CA Fire Department<br />
Frank Roberts, President & CEO - AL<br />
Solutions<br />
Preston Baucom, EHS Director - ATI<br />
Specialty <strong>Material</strong>s<br />
Tom Schaffer, Management - Schaffer<br />
Grinding Co., Inc.<br />
Karen Jones, Health, Safety &<br />
Environmental Manager - TIMET<br />
=<br />
Conclusions<br />
In conclusion, our present investigation<br />
demonstrates that special processing of<br />
titanium middle ear implants leads to<br />
increased actin expression and increased<br />
coverage by fibroblasts. The cell growth<br />
on the prosthesis is a main indicator of<br />
its biocompatibility. Furthermore, cell<br />
growth supports the stable integration<br />
of the implant within the reconstructed<br />
ossicular chain. The effects observed in<br />
the present study suggest that this type<br />
of surface modification may be beneficial<br />
for integration in titanium middle ear<br />
prostheses. For reconstructive middle ear<br />
surgery accordingly processed titanium<br />
implants should be preferred. •<br />
Acknowledgments<br />
We are grateful to KURZ Medicals for<br />
providing the titanium platelets and<br />
thank Sara Bergmann for performing the<br />
cell cultures. This publication was funded<br />
by the German Research Foundation<br />
(DFG) in the funding programme Open<br />
Acess Publishing.<br />
Information on the authors:<br />
Kornelia Wirsching, Ear, Nose, and Throat<br />
Department, University of Regensburg,<br />
Regensburg 93042, Germany<br />
Karla Lehle, Cardiothoracic Surgery<br />
Department, University of Regensburg,<br />
Regensburg 93042, Germany<br />
Peter Jacob, Ear, Nose, and Throat<br />
Department, Sørlandet Sykehus, Kristiansand<br />
N-4600, Norway<br />
Otto Gleich, Ear, Nose, and Throat<br />
Department, University of Regensburg,<br />
Regensburg 93042, Germany<br />
Jürgen Strutz, Ear, Nose, and Throat<br />
Department, University of Regensburg,<br />
Regensburg 93042, Germany<br />
Pingling Kwok, Ear, Nose, and Throat<br />
Department, University of Regensburg,<br />
Regensburg 93042, Germany<br />
Author to whom correspondence should be<br />
addressed:<br />
wirsching.kornelia@gmx.de<br />
Tel.: +49-941-944-9410<br />
Fax: +49-941-944-9415.<br />
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