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Dental Implants<br />

(continued from page 52)<br />

Safety Standards<br />

(continued from page 54)<br />

Biocompatibility<br />

(continued from page 27)<br />

promising and provides a basis for exciting<br />

improvements in dental implant design for<br />

patients with compromised bone healing.<br />

However, the body of research to date<br />

has still not clearly identified the optimal<br />

pore size, geometry and graduation for<br />

the most effective biomechanical and<br />

biological properties. Therefore, further<br />

studies are necessary to evaluate the<br />

potential of advanced manufacturing<br />

methods to optimize the porous titanium<br />

structure of dental implants. •<br />

Acknowledgments<br />

The authors acknowledge funding for ZJW<br />

from Iraqi Ministry of Higher Education<br />

and Scientific Research and or WvG from<br />

Orthopaedic Research UK (ORUK). The<br />

views expressed here do not necessarily<br />

represent those of ORUK.<br />

Information on the authors:<br />

Zena J. Wally 1,2,3,<br />

William van Grunsven 1,2,<br />

Frederik Claeyssens 1,2,3,<br />

Russell Goodall 1<br />

Gwendolen C. Reilly 1,3,*<br />

Department of <strong>Material</strong>s Science and<br />

Engineering, University of Sheffield, Sir<br />

Robert Hadfield Building, Mappin St,<br />

Sheffield S1 3JD, UK; E-Mails: zjwally1@<br />

sheffield.ac.uk (Z.J.W.); w.vangrunsven@<br />

gmail.com (W.G.); f.claeyssens@sheffield.<br />

ac.uk (F.C.); r.goodall@sheffield.ac.uk (R.G.)<br />

(2) Kroto Research Institute, University of<br />

Sheffield, Broad Lane, Sheffield S3 7HQ,<br />

UK<br />

(3) Insigneo Institute for in silico Medicine,<br />

University of Sheffield, Pam Liversidge<br />

Building, Mappin St, Sheffield S1 3JD, UK<br />

Author to whom correspondence should be<br />

addressed:<br />

E-Mail: g.reilly@sheffield.ac.uk<br />

Tel.: +44-0-114-222-5986<br />

Fax: +44-0-114-222-5943<br />

of the existing standards in IATA, DOT,<br />

OSHA, EPA and NFPA for determining<br />

flammability and combustibility of<br />

titanium are acceptable and might<br />

truly reflect what the industry is now<br />

producing and how it is being processed.<br />

“If that is the result, then the ITA Safety<br />

Committee can take the position that<br />

we recognize there have been a lot of<br />

changes in the past 50 years; that the<br />

community has assessed to the best of<br />

its ability that industry is on the proper<br />

course, and the resulting information<br />

will be provided to the ITA membership,”<br />

Lee said. “Conversely, Phase 1 may result<br />

in finding that some testing standards<br />

are incorrect, incomplete or obsolete<br />

and there may need to be a fundamental<br />

examination of what those should be.<br />

After the data and practices are collected<br />

and before any final decisions are<br />

made, ITA will organize a committee of<br />

experts including experts from outside<br />

the industry to conduct an appropriate<br />

peer review to increase the potential for<br />

getting it right.”<br />

This initiative is a continuation of<br />

the Safety Committee’s efforts to bring<br />

awareness to all safety issues when<br />

handling and working with titanium.<br />

Visit the ITA’s website (titanium.org)<br />

for more information on the work of the<br />

Safety Committee. •<br />

ITA 2016 Safety Executive<br />

Committee Members:<br />

Robert Lee, President - Accushape Inc.<br />

(Chair)<br />

Dietmar Fisher, Consultant, Dipl.-Ing. -<br />

Titanium Consultancy & Training<br />

Kevin Kreitman, Safety Consultant -<br />

Retired Redding CA Fire Department<br />

Frank Roberts, President & CEO - AL<br />

Solutions<br />

Preston Baucom, EHS Director - ATI<br />

Specialty <strong>Material</strong>s<br />

Tom Schaffer, Management - Schaffer<br />

Grinding Co., Inc.<br />

Karen Jones, Health, Safety &<br />

Environmental Manager - TIMET<br />

=<br />

Conclusions<br />

In conclusion, our present investigation<br />

demonstrates that special processing of<br />

titanium middle ear implants leads to<br />

increased actin expression and increased<br />

coverage by fibroblasts. The cell growth<br />

on the prosthesis is a main indicator of<br />

its biocompatibility. Furthermore, cell<br />

growth supports the stable integration<br />

of the implant within the reconstructed<br />

ossicular chain. The effects observed in<br />

the present study suggest that this type<br />

of surface modification may be beneficial<br />

for integration in titanium middle ear<br />

prostheses. For reconstructive middle ear<br />

surgery accordingly processed titanium<br />

implants should be preferred. •<br />

Acknowledgments<br />

We are grateful to KURZ Medicals for<br />

providing the titanium platelets and<br />

thank Sara Bergmann for performing the<br />

cell cultures. This publication was funded<br />

by the German Research Foundation<br />

(DFG) in the funding programme Open<br />

Acess Publishing.<br />

Information on the authors:<br />

Kornelia Wirsching, Ear, Nose, and Throat<br />

Department, University of Regensburg,<br />

Regensburg 93042, Germany<br />

Karla Lehle, Cardiothoracic Surgery<br />

Department, University of Regensburg,<br />

Regensburg 93042, Germany<br />

Peter Jacob, Ear, Nose, and Throat<br />

Department, Sørlandet Sykehus, Kristiansand<br />

N-4600, Norway<br />

Otto Gleich, Ear, Nose, and Throat<br />

Department, University of Regensburg,<br />

Regensburg 93042, Germany<br />

Jürgen Strutz, Ear, Nose, and Throat<br />

Department, University of Regensburg,<br />

Regensburg 93042, Germany<br />

Pingling Kwok, Ear, Nose, and Throat<br />

Department, University of Regensburg,<br />

Regensburg 93042, Germany<br />

Author to whom correspondence should be<br />

addressed:<br />

wirsching.kornelia@gmx.de<br />

Tel.: +49-941-944-9410<br />

Fax: +49-941-944-9415.<br />

TITANIUMTODAY 61

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