Effects of isochaborat testosterone on the kidney rats

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List of FiguresFigure No. Title Page No.Figure (1) Kidneys in a cadaver 6Figure (2) Kidneys in situ 7Figure (3) Internal anatomy of the kidney 9Figure (4) Urogenital System of rat 12Figure (5) Steroid pathways in Leydig cells 13Figure (6) Regulation of Leydig cell steroidogenesis by luteinizing hormone 15negative-feedback loopFigure (7) Chemical structure of testosterone 16Figure (8) Chemical structures of some synthetic (AAS) 17Figure (9) Mechanism of action of exogenous anabolic steroids 18Figure (10) Flowchart of positive and negative effects of (AAS) administration 20Figure (11) LM of kidney of control male rat 200x 53Figure (12) LM of kidney of control male rat 400x 54Figure (13) EM of the DCT of kidney of control group rats 2000x 55Figure (14) LM of kidney treated with (Sustanon ®250) 50 mg/kg B.W 200x 56Figure (15) LM of kidney treated with (Sustanon ®250) 50 mg/kg B.W 400x 57Figure (16) EM of of kidney treated with (Sustanon ®250) 50 mg /kg B.W 58(2000X)Figure (17) EM of of kidney treated with (Sustanon ®250) 50 mg /kg B.W 59(4000X)Figure (18) LM of kidney treated with (Sustanon ®250) 100 mg/kg 200x 60Figure (19) LM of kidney treated with (Sustanon ®250) 100 mg/kg 400x 61Figure (20) EM of of kidney treated with (Sustanon ®250) 100 mg /kg (2000X) 62Figure (21) EM of of kidney treated with (Sustanon ®250) 100 mg /kg (4000x) 63Figure (22) LM of kidney treated with (Sustanon ®250) 150 mg/kg 200x 64Figure (23) LM of kidney treated with (Sustanon ®250) 150 mg/kg 400x 65Figure (24) EM of DCT of kidney treated with (Sustanon ®250) 150 mg /kg. 66(2000X)Figure (25) EM of DCT of kidney treated with (Sustanon ®250) 150 mg /kg.(4000X)67IV
List of AbbreviationsAASsARAREsDHTFAIFSHGDGnRHHand EHDLHPGIGFLHMMPNDPSARAASROSSHBGT/ET/LHTMTUUGTVEGFWADAAnabolic-Androgenic SteroidsAndrogen ReceptorAndrogen Response ElementsDihydrotestosteroneFree Androgen IndexFollicle Stimulating HormoneGender DysphoriaGonadotropin-Releasing HormoneHematoxylin and EosinHigh-Density LipoproteinHypothalamic-Pituitary-GonadalInsulin-Like Growth FactorLuteinizing HormoneMatrix metalloproteinasesNandrolone DecanoateProstate-Specific AntigenRenin-Angiotensin-Aldosterone SystemReactive Oxygen SpeciesSex Hormone-Binding GlobulinTestosterone to EpitestosteroneTestosterone/Luteinizing HormoneTransgender MalesTestosterone UndecanoateUridine Diphospho-Glucuronosyl TransferaseVascular Endothelial Growth FactorWorld Anti-Doping AgencyV
Page 1: Histopatholgical Effects of Testeos
Page 4 and 5: List of contentsAcknowledgements...
Page 8 and 9: IntroductionIntroductionIt has been
Page 10 and 11: Aim of the WorkAim of the workThe a
Page 12 and 13: Review of Literature1.Anatomy of hu
Page 14 and 15: Review of LiteratureFigure (2): Kid
Page 16 and 17: Review of LiteratureFigure (3): Int
Page 18 and 19: Review of Literaturearterioles to r
Page 20 and 21: Review of Literature3. Biochemistry
Page 22 and 23: Review of LiteratureFigure (6): Reg
Page 24 and 25: Review of LiteratureFigure (8): Che
Page 26 and 27: Review of LiteratureAAS exert their
Page 28 and 29: Review of LiteratureMoreover, testo
Page 30 and 31: Review of Literature5.2.Abuse of AA
Page 32 and 33: Review of LiteratureAutopsy plays a
Page 34 and 35: Review of Literaturethere were incr
Page 36 and 37: Review of LiteratureIt was demonstr
Page 38 and 39: Review of LiteratureFurthermore, du
Page 40 and 41: Review of LiteratureSalivary testos
Page 42 and 43: Materials and MethodsDuring the pre
Page 44 and 45: Materials and Methods1.6.Chemicals:
Page 46 and 47: Materials and Methodsno natural col
Page 48 and 49: Materials and Methods2.1. Fixation:
Page 50 and 51: Materials and Methods2.6.1.Preparat
Page 52 and 53: Materials and Methods2.9.1.Preparat
Page 54 and 55: Materials and Methods4. Digital mor
Page 56 and 57:
Materials and Methodsachieved autom
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Mean ± SDResults300250200226.2215.
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Histological structure of the kidne
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Results(Fig. 12): Light micrograph
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Group (II):Results(Treated with IM
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Results(Fig. 16): Transmission elec
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Group III:Results(Treated with (Sus
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Results(Fig. 20): Transmission elec
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Group IV:Results(Was treated with (
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ResultsBMM(Fig. 24): Transmission e
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DiscussionDiscussionIn recent years
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Discussioncreatinine, albumin….et
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Discussionassociation between the u
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Summary and conclusionSummary and c
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RecommendationsRecommendations1- At
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ReferencesAndersen S.B., Taghavi I.
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ReferencesChristiansen S., and Liok
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ReferencesHavnes, Innerdal I., and
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ReferencesMaly S., Janousek L., Seb
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ReferencesSalerno M., Cascio O., an
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ReferencesVilar Neto J.d.O., da Sil
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Effects of isochaborat testosterone on the kidney rats

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