The Staphylococcus aureus secretome - TI Pharma

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Paranimfen: Thijs R.H.M. Kouwen Monika A. Chlebowicz Voor Regina Voor Pap “I’ll always remember the chill of November” “Carpe diem - seize the day” “Look around, hear the sounds Cherish your life while you’re still around” “Seize the day and don't you cry, now it's time to say goodbye Even though I'll be gone, I will live on” -Dream <strong>The</strong>ater – “A Change Of Seasons”- “Thank you for the inspiration, thank you for the smiles All the unconditional love that carried me for miles It carried me for miles But most of all: thank you for my life” -Dream <strong>The</strong>ater – “Best Of Times”- 5
Page 2: The Staphylococcus aureus secretome
Page 6: RIJKSUNIVERSITEIT GRONINGEN The Sta
Page 12: The work described in this thesis w
Page 16: "The greatest education in the worl
Page 20: Chapter 1 Introduction Bacteria are
Page 24: Chapter 1 Scope of this thesis Due
Page 28: “Music is a moral law It gives so
Page 32: Chapter 2 Summary The Gram-positive
Page 36: Chapter 2 18 A B Figure 1. Imaging
Page 40: Chapter 2 cells of S. aureus can pe
Page 44: Chapter 2 PBP2a is encoded by the m
Page 48: Chapter 2 each other. However, anal
Page 52: Chapter 2 of virulence factors to t
Page 56: Chapter 2 homologues are not essent
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Chapter 2 The S. aureus Lgt is a pr
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Chapter 2 view is confirmed by comp
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Chapter 2 Holins Holins are dedicat
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Chapter 2 Figure 5. General propert
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Chapter 2 exoproteome and variant e
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Chapter 2 that these proteins are d
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Chapter 2 is plasmid-encoded in S.
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Chapter 2 membrane (Tokuda and Mats
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Chapter 2 sortases recognize a diff
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Chapter 2 Five additional proteins
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Chapter 2 surprises when such pathw
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Chapter 3 Proteogenomics uncovers e
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Proteogenomics uncovers extreme het
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Chapter 4 Characterization of Staph
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Introduction Characterization of St
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Characterization of Staphylococcus
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RN4220 OD 540 of 20 RN4220 ∆comGA
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“Besides being a guitar player, I
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Chapter 5 Summary The Gram-positive
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Chapter 5 the membrane spanning dom
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Chapter 5 Table 2. Primers used in
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Chapter 5 incubated at 95ºC. Prote
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Chapter 5 Table 3A: Cell wall prote
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Chapter 5 geh RN4220 RN4220∆secG
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Chapter 5 Discussion The extracellu
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Chapter 5 Acknowledgements We like
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“One good thing about music:when
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Chapter 6 Summary Staphylococcus au
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Chapter 6 for yhcS mutant strains c
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Chapter 6 Table 1. Bacterial strain
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Chapter 6 with S. aureus srtA or S.
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Chapter 6 Biofilm formation Biofilm
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Chapter 6 Table 3. Extracellular pr
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Chapter 6 Complementation analysis
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Chapter 6 observed for SasG-overpro
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Chapter 6 substrates that are also
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“Without music, life would be a m
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Chapter 7 Summary Bacillus subtilis
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Chapter 7 Materials and Methods Bac
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Chapter 7 Mutants of S. aureus were
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Chapter 7 we deployed this assay to
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Chapter 7 NaCl affects the sublanci
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Chapter 7 since the growth of B. su
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Chapter 7 Discussion In the present
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Chapter 7 Acknowledgements We thank
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“Although one can get very clever
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Chapter 8 Summary The now finished
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Chapter 8 Materials and methods Str
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Chapter 8 The extracellular proteom
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Chapter 8 There were also some cell
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Chapter 8 secreted only at a low le
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Chapter 8 by glucose as well as by
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“I will choose free will” -Neil
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Chapter 9 General summary and discu
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Chapter 9 Systematic analysis of tr
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Chapter 9 sequence of B. lichenifor
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“Good music is good music and eve
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Chapter 10 Adhikari, R.P., and Novi
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Chapter 10 Burts, M.L., Dent, A.C.,
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Chapter 10 Fedtke, I., Götz, F., a
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Chapter 10 Huard, C., Miranda, G.,
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Chapter 10 Marraffini, L.A., Ton-Th
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Chapter 10 Otto, M. (2008) Targeted
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Chapter 10 Siegers, K., Heinzmann,
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Chapter 10 Vrontou, E., and Economo
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“I only got seventh-grade educati
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Chapter 11 Nederlandse samenvatting
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Chapter 11 Inleiding - Hoofdstuk 1
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Chapter 11 verwijderen van deze com
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Chapter 11 gemaakt, maar er was nog
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Appendix I Dankwoord En nu je einde
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Appendix I regelmatig schoonmaken h
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202
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Appendix II Publication list Public
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Appendix III: Supplemental tables t
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Appendix III Supplemental Table III
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Appendix IV Supplemental Table IVa
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Appendix IV Supplemental Table IVb
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Appendix IV Supplemental Table IVc
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Appendix V Supplemental Table Va ID
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Appendix V Supplemental Table Vb Su
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Appendix V Supplemental Table Vb Pr
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Appendix V Supplemental Table Vb Pr
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Appendix V Supplemental Table Vc Pr
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