Download Complete Issue (pdf 3800kb) - Academic Journals

More documents

Recommendations

Info

1924 Afr. J. Pharm. Pharmacol. Figure 1. A, In invasive ductal carcinoma tissue KAI1 is lowly expressed in cell membrane and cytoplasm (×200); B, In benign breast tissue, KAI1 is highly expressed in cell membrane and cytoplasm (×200); C, In invasive ductal carcinoma tissue MMP-2 is positively expressed in cell membrane and cytoplasm (×200); D, In benign breast tissue MMP-2 is lowly expressed in cell membrane and cytoplasm (X×200). June, 2011 treated with radical mastectomy for invasive ductal breast cancer in our department was retrospectively recruited in this study. The diagnoses were confirmed with pathological sample dissected from the surgery, and all patients were without prechemotherapy. The patients were divided according to tumornodes-metastasis (TNM) grades: 14 cases of stage I, 29 cases of stage II, and 17 cases of stage III, or by histological grades: 29 cases of stage I, 17 cases of stage II, and 14 cases of stage III. Twenty-seven (27) cases of patients showed tumor size more than 5 cm. Twenty-one (21) cases of patients showed lymph node metastasis. Fifteen (15) patients have post-menopausal. Thirty (30) cases of subjects (25 to 70 years old, averaged at 44.8 ± 9.7 years old) with benign breast cancer tissue samples were recruited as control group. There were no differences in the age composition of the two groups (P>0.05). The study has been approved by Local Ethic Committee of human research and has the informed written consent of all patients. Immunohistochemistry The samples obtained during surgery were fixed in 10% neutral formalin solution, and processed for 5 µm paraffin sections. The mouse-anti human KAI1 and MMP-2 monoclonal antibody (1:200, Jinqiao, Beijing) were incubated overnight at 4°C and finally the reaction was visualized with 3,3'-diaminobenzidine (DAB) approach. Then sections were examined under microscope and 5 areas per section were randomly selected for counting of positive cells. The positive cell rate were recorded as negative (–) for < 5%, positive (+) for 5 to 25%, ++ for 25 to 50%, and +++ for >50%. Statistics All data were represented as mean ± standard deviation (SD) and analyzed with SPSS 13.0 software (Chicago, US). The � 2 test was used to examine the relationship between the expression of KAI1/MMP-2 and the clinical characteristics; the correlationship was examined with Pearson test; P
Table 1. The expression of KAI1 and MMP-2 in breast cancer and control groups. Group n Positive (cases) KAI1 Negative (cases) Positive rate (%) Positive (cases) MMP-2 Negative (cases) Positive rate (%) Breast cancer 60 25 35 41.7* 48 12 80.0* Control 30 25 5 83.3 5 25 16.7 x 2 5.328 12.777 P 0.000 0.000 *, P0.05 Lymph node metastasis Tumor size TNM stage Histological stages Menstruation The expression of KAI1 and MMP-2 in breast cancer patients with different clinical features Within the breast cancer patients, the group with lymph node metastasis showed higher positive rate of KAI1 and MMP2 expression than those without lymph node metastasis (P
Page 1 and 2: African Journal of Pharmacy and Pha
Page 3 and 4: Editors Sharmilah Pamela Seetulsing
Page 5 and 6: Electronic submission of manuscript
Page 7 and 8: Fees and Charges: Authors are requi
Page 9 and 10: Table of Contents: Volume 6 Number
Page 13 and 14: Minimum inhibitory concentration (M
Page 15 and 16: Kim et al. 1887 Table 4. Antimicrob
Page 17 and 18: Klevens RM, Morrison M A, Nadle J,
Page 19 and 20: Figure 1. Chemical structure of ten
Page 21 and 22: ng/ml by 4.9 ml blank plasma with 5
Page 23 and 24: Figure 5. Chromatogram of plasma sp
Page 25 and 26: Figure 7. Chromatogram of a healthy
Page 27 and 28: Figure 11. Chromatograms of standar
Page 31 and 32: Shatoor 1903 Figure 1. The effect o
Page 33 and 34: Heart rate (Beats/min.) 345 330 315
Page 35 and 36: Table 2. Percent of changes in hear
Page 37 and 38: heart rate on coronary flow and car
Page 39 and 40: Urinary tract infections are the mo
Page 41 and 42: Table 1. Study characteristics of i
Page 43 and 44: Table 1. contd. Sun GQ 37 007 Ross
Page 45 and 46: Study or Subgroup Cai SF 2003 Gao H
Page 47 and 48: Study or Subgroup Cai SF 2003 Gao H
Page 49 and 50: cure rate and clinical effective ra
Page 51: African Journal of Pharmacy and Pha
Page 57 and 58: Figure 2. Typical chromatograms of
Page 59 and 60: Excretion studies Figure 4 shows th
Page 63 and 64: Table 1. Statistical results of the
Page 65 and 66: ethinylestradiol /100 g levonorgest
Page 67 and 68: HO CH 2OH O OH OH OCH 2CH 2 OH Figu
Page 69 and 70: A B Figure 3. Bax positive cells of
Page 73 and 74: Table 1. Summary of specific reacti
Page 75 and 76: Figure 3. Effects of the sap of Jat
Page 79 and 80: Figure 1. A schematic diagram showi
Page 81 and 82: Chen et al. 1953 Figure 4. Concentr
Page 83 and 84: Figure 6. Representative photomicro
Page 85 and 86: shock. The features of PHC can expl
Page 87 and 88: Administration of single or repeate
Page 89 and 90: Table 1. Effects of green tea on SO
Page 91 and 92: Ozardali I, Bitiren M, Ali ZK, Zeri
Page 93 and 94: EXPERIMENTAL PROCEDURE Materials an
Page 95 and 96: Scavenging rate (%) Figure 1 Scaven
Page 97 and 98: A D Figure 5 Figure Effects 5. of E
Page 101 and 102: Figure 1. Level-spacing distributio
Page 103 and 104:
Number of cases Pattern Shi et al.
Page 105 and 106:
African Journal of Pharmacy and Pha
Page 107 and 108:
sodium was then dissolved in 1000 m
Page 109 and 110:
Concentration (ppm) Concentration (
Page 111 and 112:
various contagious diseases such as
Page 113 and 114:
Table 3. Antibacterial MIC (µg/ml)
Page 115 and 116:
Table 5. Contd. 1/5 14.7 ± 0.6 39.
Page 117 and 118:
UPCOMING CONFERENCES 6th European C
Page 119:
African Journal of Pharmacy and Pha
show all

Download Complete Issue (pdf 3800kb) - Academic Journals

Create successful ePaper yourself

Delete template?

Save as template?