Schede di attivitÃ - Epidemiologia eziologica / 2012 - CPO

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Epidemiologia eziologicaCentro di Riferimento per l'Epidemiologia e la Prevenzione Oncologica in PiemonteScheda: 4.006Studio europeo sui tumori rariRare cancers in EuropeRESPONSABILE: Prof. Franco MERLETTICOORDINAMENTO:Studio multicentricoOBIETTIVI GENERALI E SINTESI PROGETTO:Obiettivo del progetto è identificare fattori di rischio per tumori rari ad eziologia ignota, conparticolare riferimento a fattori occupazionali.MATERIALI, METODI E RISULTATI ATTESI:Tutti i casi incidenti di 7 sedi tumorali (melanoma dell’occhio, micosi fungoide, osso, mammellamaschile, vie biliari maschili, timo) ed un gruppo di controlli sono stati identificati in uno studiocaso-controllo di popolazione che si svolge in 9 paesi europei con 3 centri italiani. Il centro diTorino funge da coordinamento per l’Italia e fornisce il principal investigator europeo per la sedetumorale osso.STATO DI AVANZAMENTO AL 31/12/2011:La raccolta dati è terminata nel 1998 (circa 2.000 casi e 4.000 controlli). Sono stati validati i datiraccolti e sono stati pubblicati a tutt’oggi 16 articoli. Altri articoli sono in corso di stesura. Nel 2012è prevista la continuazione delle analisi dei dati e della pubblicazione dei risultati.Sono ancora attesi da 3 a 6 articoli.COLLABORATORI INTERNI:Lorenzo RICHIARDICOLLABORATORI ESTERNI:Lorenzo Simonato, Enzo Merler.RISORSE E FINANZIAMENTO:Biomed, Ministero del Lavoro Italiano, 60%MURST, Associazione Italiana Ricerca sul Cancro,Compagnia di San Paolo.PUBBLICAZIONI:• BEHRENS T, LYNGE E, CREE I, LUTZ JM, ERIKSSON M, GUÉNEL P, MERLETTI F, MORALES-SUAREZ-VARELA M,AFONSO N, STENGREVICS A, STANG A, FÉVOTTE J, SABROE S, LLOPIS-GONZÁLEZ A, GORINI G, HARDELL L,AHRENS W. OCCUPATIONAL EXPOSURE TO ENDOCRINE-DISRUPTING CHEMICALS AND THE RISK OF UVEALMELANOMA. SCAND J WORK ENVIRON HEALTH. 2011 DEC 17. PII: 3265. DOI: 10.5271/SJWEH.3265. [EPUBAHEAD OF PRINT] PUBMED PMID: 22179223.• BEHRENS T, LYNGE E, CREE I, LUTZ JM, ERIKSSON M, GUÉNEL P, MERLETTI F, MORALES-SUAREZ-VARELA M,AFONSO N, STENGREVICS A, FÉVOTTE J, SABROE S, LLOPIS-GONZÁLEZ A, GORINI G, HARDELL L, STANG A,AHRENS W. PESTICIDE EXPOSURE IN FARMING AND FORESTRY AND THE RISK OF UVEAL MELANOMA. CANCERCAUSES CONTROL. 2012 JAN;23(1):141-51. EPUB 2011 NOV 4. PUBMED PMID: 22052342.• BEHRENS T, LYNGE E, CREE I, SABROE S, LUTZ JM, AFONSO N, ERIKSSON M, GUÉNEL P, MERLETTI F,MORALES-SUAREZ-VARELA M, STENGREVICS A, FÉVOTTE J, LLOPIS-GONZÁLEZ A, GORINI G, SHARKOVA G,HARDELL L, AHRENS W. OCCUPATIONAL EXPOSURE TO ELECTROMAGNETIC FIELDS AND SEX-DIFFERENTIALRISK OF UVEAL MELANOMA. OCCUP ENVIRON MED. 2010 NOV;67(11):751-9. EPUB 2010 AUG 25. PUBMEDPMID: 20798011.• SCHMEISSER N, KAERLEV L, BOURDON-RAVERDY N, GANRY O, LLOPIS-GONZÁLEZ A, GUÉNEL P, HARDELL L,MERLETTI F, ZAMBON P, MORALES-SUÁREZ-VARELA M, OLSEN J, OLSSON H, VYBERG M, AHRENS W.OCCUPATIONAL EXPOSURE TO PESTICIDES AND BILE TRACT CARCINOMA IN MEN: RESULTS FROM AEUROPEAN MULTICENTER CASE-CONTROL STUDY. CANCER CAUSES CONTROL. 2010 SEP;21(9):1493-502.EPUB 2010 JUN 9. PUBMED PMID: 20533085• BEHRENS T, KAERLEV L, CREE I, LUTZ JM, AFONSO N, ERIKSSON M, GUÉNEL P, MERLETTI F,12
Epidemiologia eziologicaCentro di Riferimento per l'Epidemiologia e la Prevenzione Oncologica in PiemonteScheda: 4.006MORALES-SUAREZ-VARELA M, STENGREVICS A, SABROE S, CYR D, LLOPIS-GONZÁLEZ A, GORINI G, SHARKOVAG, HARDELL L, AHRENS W. HORMONAL EXPOSURES AND THE RISK OF UVEAL MELANOMA. CANCER CAUSESCONTROL. 2010 OCT;21(10):1625-34. EPUB 2010 JUN 4. PUBMED PMID: 20524054• VILLENEUVE S, CYR D, LYNGE E, ORSI L, SABROE S, MERLETTI F, GORINI G, MORALES-SUAREZ-VARELA M,AHRENS W, BAUMGARDT-ELMS C, KAERLEV L, ERIKSSON M, HARDELL L, FÉVOTTE J, GUÉNEL P. OCCUPATIONAND OCCUPATIONAL EXPOSURE TO ENDOCRINE DISRUPTING CHEMICALS IN MALE BREAST CANCER: ACASE-CONTROL STUDY IN EUROPE. OCCUP ENVIRON MED. 2010 DEC;67(12):837-44. EPUB 2010 AUG 25.PUBMED PMID: 20798010• FRITSCHI L, GUENEL P, AHRENS W; EUROPEAN STUDY GROUP ON OCCUPATIONAL CAUSES OF RARECANCERS (AUTRUP H, KOLSTAD H, KAERLEV L, SABROE S, JOHANSEN P, POULSEN S, TEGLBJAERG PS, VYBERGM, GUÉNEL P, FÉVOTTE J, ARVEUX P, BUEMI A, CARLI PM, CHAPLAIN G, DAURÈS JP, FAIVRE J, GROSCLAUDE P,GUIZARD AV, HENRY-AMAR M, LAUNOY G, MÉNÉGOZ F, RAVERDY N, SCHAFFER P, AHRENS W,BAUMGARDT-ELMS C, GOTTHARDT S, JAHN I, JÖCKEL KH, MERZENICH H, STANG A, STEGMAIER C, TIMMER A,ZIEGLER H, BALLARD T, BERTONI F, GORINI G, GOSTINICCHI S, MASALA G, MERLER E, MERLETTI F, SIMONATOL, ZAMBON P, ROGOVSKA I, SHARKOVA G, STENGREVICS A, GIBAVICIENE J, JAZUKEVICIUS L, KURTINAITIS J,POCIUTE P, ALFONSO N, COSTA-PEREIRA A, DORIA S, LOPES C, LOPES JM, MIRANDA A, SANTOS C, SANZAGUADO MA, AURREKOETXEA JJ, BRUN C, CÓRDOBA A, MARTÍNEZ GONZÁLEZ MA, GUILLÉN GRIMA F, GUARCHR, LLOPIS GONZÁLEZ A, MARÍN B, MARQUINA A, MORALES SUÁREZ-VARELA MM, AGUINAGA ONTOSO I,MARTÍNEZ PEÑUELA JM, PURAS A, VEGA F, VILLANUEVA GUARDIA MA, ERIKSSON M, HARDELL L, LARSSON I,OLSON H, SANDSTRÖM M, WINGREN G, LUTZ JM, BELL J, CREE I, FLETCHER T, FOSS AJ.). Breast cancer inpriests: follow-up of an observation made 167 years ago.Eur J Epidemiol. 2010 Mar;25(3):219-21.• AHRENS W, TIMMER A, VYBERG M, FLETCHER T, GUENEL P, MERLER E, MERLETTI F, MORALE M, OLSSON H,OLSEN J, HARDELL L, KAERLEV L, RAVERDY N, LYNGE E. Risk factors for extrahepatic biliary tract carcinoma inmen: medical conditions and lifestyle. Eur J Gastroenterol Hepatol 2007; 19: 623-30.• AHRENS W, MAMBETOVA C, BOURDON-RAVERDY N, LLOPIS-GONZÁLEZ A, GUÉNEL P, HARDELL L, MERLETTIF, MORALES-SUÁREZ-VARELA M, OLSEN J, OLSSON H, VYBERG M, ZAMBON P. Occupational exposure toendocrine-disrupting compounds and biliary tract cancer among men. Scand J Work Environ Health 2007; 33:387-96.• MERLETTI F, RICHIARDI L, BERTONI F, AHRENS W, BUEMI A, COSTA-SANTOS C, ERIKSSON M, GUENEL P,KAERLEV L, JOCKEL KH, LLOPIS-GONZALEZ A, MERLER E, MIRANDA A, MORALES-SUAREZ-VARELA MM, OLSSONH, FLETCHER T, OLSEN J. Occupational factors and risk of adult bone sarcomas: a multicentric case-controlstudy in Europe. Int J Cancer 2006; 118: 721-7.• MORALES-SUAREZ-VARELA MM, OLSEN J, JOHANSEN P, KAERLEV L, GUENEL P, ARVEUX P, WINGREN G,HARDELL L, AHRENS W, STANG A, LLOPIS A, MERLETTI F, GUILLEN-GRIMA F, MASALA G. Occupational sunexposure and mycosis fungoides: a European multicenter case-control study. J Occup Environ Med 2006; 48:390-3.• LYNGE E, AFONSO N, KAERLEV L, OLSEN J, SABROE S, AHRENS W, ERIKSSON M, GUENEL P, MERLETTI F,STENGREVICS A, SUAREZ-VARELA M, COSTA-PERERRA A, VYBERG M. European multi-centre case-control studyon risk factors for rare cancers of unknown aetiology. Eur J Cancer 2005; 41: 601-12.• LUTZ JM, CREE I, SABROE S, KVIST TK, CLAUSEN LB, AFONSO N, AHRENS W, BALLARD TJ, BELL J, CYR D,ERIKSSON M, FEVOTTE J, GUENEL P, HARDELL L, JOCKEL KH, MIRANDA A, MERLETTI F,MORALES-SUAREZ-VARELA MM, STENGREVICS A, LYNGE E. Occupational risks for uveal melanoma results froma case-control study in nine European countries. Cancer Causes Control 2005; 16: 437-47.• MORALES-SUAREZ-VARELA MM, OLSEN J, JOHANSEN P, KAERLEV L, GUENEL P, ARVEUX P, WINGREN G,HARDELL L, AHRENS W, STANG A, LLOPIS A, MERLETTI F, AURREKOETXEA JJ, MASALA G. Occupationalexposures and Mycosis Fungoides. A European multicentre case-control study (Europe). Cancer Causes Control2005; 16: 1253-9.• MORALES-SUAREZ-VARELA MM, OLSEN J, JOHANSEN P, KAERLEV L, GUENEL P, ARVEUX P, WINGREN G,HARDELL L, AHRENS W, STANG A, LLOPIS A, MERLETTI F, AURREKOETXEA JJ, MASALA G. Occupational riskfactors for mycosis fungoides: a European multicenter case-control study. J Occup Environ Med 2004; 46):205-11.• GUENEL P, CYR D, SABROE S, LYNGE E, MERLETTI F, AHRENS W, BAUMGARDT-ELMS C, MENEGOZ F, OLSSONH, PAULSEN S, SIMONATO L, WINGREN G. Alcohol drinking may increase risk of breast cancer in men: aEuropean population-based case-control study. Cancer Causes Control 2004; 15: 571-80.• MORALES MM, OLSEN J, JOHANSEN P, KAERLEV L, GUENEL P, ARVEUX P, WINGREN G, HARDELL L, AHRENS W,STANG A, LLOPIS A, MERLETTI F, VILLANUEVA MA. Viral infection, atopy and mycosis fungoides: a Europeanmulticentre case-control study. Eur J Cancer 2003; 39: 511-6.• MORALES SUAREZ-VARELA MM, OLSEN J, KAERLEV L, GUENEL P, ARVEUX P, WINGREN G, HARDELL L,AHRENS W, STANG A, LLOPIS A, MERLETTI F, GUILLEN F. Are alcohol intake and smoking associated withmycosis fungoides? A European multicentre case-control study. Eur J Cancer 2001; 37: 392-7.• KAERLEV L, TEGLBJAERG PS, SABROE S, KOLSTAD HA, AHRENS W, ERIKSSON M, GUENEL P, HARDELL L,LAUNOY G, MERLER E, MERLETTI F, STANG A. Medical risk factors for small-bowel adenocarcinoma with focuson Chron disease: a European population-based case-control study. Scand J Gastroenterol 2001; 36: 641-6.• KAERLEV L, TEGLBJAERG PS, SABROE S, KOLSTAD HA, AHRENS W, ERIKSSON M, GUENEL P, HARDELL L,LAUNOY G, MERLER E, MERLETTI F, STANG A, OLSEN J. Is there an association between alcohol intake orsmoking and small bowel adenocarcinoma? Results from a European multi-center case-control study. CancerCause Control 2000; 11: 791-7.• KAERLEV L, TEGLBJAERG PS, SABROE S, KOLSTAD HA, AHRENS W, ERIKSSON M, GONZALEZ AL, GUENEL P,HARDELL L, LAUNOY G, MERLER E, MERLETTI F, SUAREZ-VARELA MM, STANG A. Occupation and small boweladenocarcinoma: a European case-control study. Occup Environ Med 2000; 57: 760-6.13
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