Products at a Glance 2024

www.pelobiotech.com

www.pelobiotech.com Tissues We provide researchers with high quality human tissue samples sourced from various organs. These samples exhibit high RIN scores and are available from both healthy and diseased donors. Our extensive donor information includes details such as gender, age, ethnicity, BMI, cause of death, smoking and alcohol use history, HLA typing, and past medical records. Applications Spinal sections encompass a wide range of uses, including target profiling and engagement, spatial omics analysis, functional and structural interrogation, and their role in CNS drug discovery. Additionally, they are crucial in studying neurotoxicity and neuropathy, contributing significantly to the field of neurological research. Lung sections find application in studying cytokine release, gene expression, immune cell activation, transcriptomics, and proteomics. They are instrumental in investigating airway contraction and relaxation dynamics and the regulation of blood vessel constriction and dilation, making them vital tools for respiratory research. Heart sections play a pivotal role in target expression and localization studies, spatial omics analysis, functional assays, and action potential measurements. They are essential for understanding proarrhythmia, inotropic effects, force production, vascular tone regulation, and the assessment of chamber-specific efficacy and safety, thereby contributing to cardiovascular research and drug development. Dorsal root ganglia sections are employed in target profiling and engagement, as well as functional and structural interrogation. They play a crucial role in pain and itch drug discovery, as well as research related to neurotoxicity and neuropathy, enhancing our understanding of sensory and peripheral nervous systems. Brain sections offer valuable insights into target expression and localization, spatial omics, immunocytochemistry, and the application of RNAscope technology. They are indispensable in neuroscientific research, providing a foundation for understanding neural processes and cellular interactions in the brain. 24

www.pelobiotech.com Cell and Tissue RNA The use of RNA from various cells and diseased cells of individuals offers a wide range of applications in research and medicine, including: • Gene Expression Profiling: Analyzing RNA from different cells allows researchers to profile gene expression patterns, which can provide insights into the cellular functions and regulatory mechanisms. • Disease Biomarker Discovery: Differential gene expression analysis using RNA can help identify potential biomarkers associated with diseases, aiding in early diagnosis and monitoring of various conditions. • Drug Development and Testing: RNA from disease-specific cells can be used to screen potential drug candidates, evaluate their effectiveness, and assess their impact on specific genetic pathways. • Precision Medicine: RNA analysis can guide the development of personalized treatment strategies by understanding the genetic basis of individual diseases and tailoring therapies accordingly. • Understanding Disease Mechanisms: Investigating RNA from diseased cells can provide valuable information about the underlying molecular mechanisms of various conditions, which is crucial for advancing our understanding of diseases. • Functional Genomics: RNA interference (RNAi) and CRISPR-based technologies can be applied to manipulate gene expression in cells, enabling the study of gene function and regulation. • Comparative Genomics: Comparing RNA from different cell types and states can help researchers better understand the genetic variations and functional differences between healthy and diseased cells. • Stem Cell Research: RNA analysis is critical for characterizing the differentiation and pluripotency of stem cells, which is vital in regenerative medicine and tissue engineering. • Viral and Pathogen Detection: RNA-based techniques can be used to detect the presence of viral RNA, making it a valuable tool in diagnosing infectious diseases. • Biotechnology and Biomedical Research: RNA is essential for the development of molecular tools, such as RNA vaccines, RNA-based therapeutics, and RNA sequencing (RNA-Seq) technologies. However, the production of the same involves a time-consuming and multi-step process, starting from the dissociation of tissues and hoping for an adequate yield of cDNA. Instead of navigating through these time-intensive procedures that span weeks, just purchase our RNA isolated from different tissues and individuals with disease. We also offer RNA isolation kits for those who prefer to undertake the work independently. 25