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8. Summary73 patients with lymph nodes enlargement were classified, according WHO lymphomaclassification into DLBCL (53 cases) and FL-3 predominantly follicular arhitecture,>75% (20 cases). Expression of markers was detected by immunohistochemical methodand cytogenetic abnormalities were analysed by FISH.The results have shown no differences in survival of DLBCL and FL-3 predominantlyfollicular arhitecture, >75%, which are two different morphological entities accordingWHO classification, but differences in patients age and IPI were detected. In cases ofDLBCL and FL-3 were not found differences in BCL2, BCL6 genes abnormalities andBCL2 protein expression. The BCL6 protein expression was more frequently found inFL-3. Morphological entities DLBCL and FL-3 were equal represent in GCB and ABCgroups, which were defined according CD10, BCL6, MUM1/IRF4 and CD138expression. The t(14;18)(q32;q21) was more frequently found in the GCB group, andt(14;18)(q32;q21) with additional BCL2 signals or only additional BCL2 and IgH signalsin the ABC group. t(14;18)(q32;q21) represent an initial mechanism in the pathogenesisof GCB group. Amplification of BCL2 gene is frequently present in ABC group. In theGCB and ABC groups were not detected differences in BCL6 gene abnormanlities.Multivariate regression analysis was shown no prognostic significance of the expressionof each BCL6 and CD10 protein expression, the BCL2 and BCL6 genes abnormalitiesand the IPI. Also in GCB and ABC groups were not detected differences in the IPI.GCB and ABC immunophenotype groups were defined as independent prognosticpredictors.