66. Lossos IS, Alizadeh AA, Eisen MB, et al. Ongoing immunoglobulin somatic mutation in germinalcenter B cell-like but not in activated B cell-like diffuse large cell lymphomas. Proc Natl Acad SciUSA 2000;97:10209-13.67. Rosenwald A, Wright G, Chan WC, et al. The use of molecular profiling to predict survival afterchemotherapy for diffuse large-B-cell lymphoma. N Engl J Med 2002;346:1937-47.68. Wright G, Tan B, Rosenwald A, Hurt EH, Wiestner A, Staudt LM. A gene expression-based method todiagnose clinically distinct subgroup of diffuse large B cell lymphoma. Proc Natl Acad Sci USA2003;100:9991-6.69. Shipp MA, Ross KN, Tamayo P, et al. Diffuse large B-cell lymphoma outcome prediction by geneexpressionprofiling and supervised machine learning. Nat Med 2002;8:68-74.70. Monti S, Savage KJ, Kutok JL, et al. Molecular profiling of diffuse large B-cell lymphoma identifiesrobust subtypes including one characterized by host inflammatory response. Blood 2005;105:1851-61.71. Lossos IS, Czerwinski DK, Alizadeh AA, et al. Prediction of survival in diffuse large B-cell lymphomabased on the expression of six genes. N Engl J Med 2004;350:1828-37.72. Kobayashi T, Yamaguchi M, Kim S, et al. Microarray reveals differences in both tumors and vascularspecific gene expression in de novo CD5+ and CD5- diffuse large B-cell lymphomas. Cancer Res2003;63:60-6.73. Rosenwald A, Staudt LM. Clinical translation of gene expression profiling in lymphomas andleukemias. Semin Oncol 2002;29:258-63.74. Van't Veer LJ, De Jong D. The microarray way to tailored cancer treatment. Nat Med 2002;8:13-14.75. Robetorye RS, Bohling SD, Morgan JW, Fillmore GC, Lim MS, Elenitoba-Johnson KS. Microarrayanalysis of B-cell lymphoma cell lines with the t(14;18). J Mol Diag 2002;4:123-36.76. Dybkaer K, Iqbal J, Zhou G, Chan WC. Molecular diagnosis and outcome prediction in diffuse largeB-cell lymphoma and other subtypes of lymphoma. Clin Lymphoma 2004;5:19-28.77. Husson H, Carideo EG, Neuberg D, et al. Gene expression profiling of follicular lymphoma andnormal germinal center B cells using cDNA arrays. Blood 2002;99:282-9.
78. Lossos IS, Alizadeh AA, Diehn M, et al. Transformation of follicular lymphoma to diffuse large-celllymphoma: alternative patterns with increased or decreased expression of c-myc and its regulatedgenes. Proc Natl Acad Sci USA 2002;99:8886-91.79. Martinez-Climent JA, Alizadeh AA, Segraves R, et al. Transformation of follicular lymphoma todiffuse large cell lymphoma is associated with a heterogeneous set of DNA copy number and geneexpression alterations. Blood 2003;101:3109-17.80. Sigal S, Ninette A, Rechavi G. Microarray studies of prognostic stratification and transformation offollicular lymphomas. Best Pract Res Clin Haematol 2005;18:143-56.81. Falini B, Mason DY. Proteins encoded by genes involved in chromosomal alterations in lymphomaand leukemia: clinical value of their detection by immunocytochemistry. Blood 2002;99:409-26.82. deLeval L, Harris NL. Variability in immunophenotype in diffuse large B-cell lymphoma and itsclinical relevance. Histopathology 2003;43:509-28.83. Gascoyne R. Emerging prognostic factors in diffuse large B cell lymphoma. Curr Opin Oncol2004;16:436-41.84. Bai M, Skyrlas A, Agnantis NJ, et al. B-cell differentiation, apoptosis and proliferation in diffuse largeB-cell lymphomas. Anticancer Res 2005;25:347-62.85. Dalla-Favera R, Ye BH, Lo Coco F, et al. Identification of genetic lesions associated with diffuselarge-cell lymphoma. Ann Oncol 1994;5:55-60.86. Ye BH, Cattoretti G, Shen Q, et al. The Bcl-6 proto-oncogene controls germinal-centre formation andTh2-type inflammation. Nat Genet 1997;16:161-70.87. Reljic R, Wagner SD, Peakman LJ, Fearon DT. Suppression of signal transducer and activator oftranscription 3-dependent B lymphocyte terminal differentiation by BCL-6. J Exp Med2000;192:1841-8.88. Falini B, Fizzotti M, Pileri S, Liso A, Pasqualucci L, Flenghi L. BCL-6 protein expression in normaland neoplastic lymphoid tissues. Ann Oncol 1997;8:101-4.
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Središnja medicinska knjižnicaBor
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Disertacija je izrađena u Odjelu z
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3.4 Interfazna fluorescentna in sit
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H&E - hemalaun & eozinHIV - virus h
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klasifikacije limfoidnih neoplazmi
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Folikularni limfom (FL) - 25% svih
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simptoma. MPI obuhvaća dob bolesni
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1.4 DNA microarray analiza genske e
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molekularno različitih bolesti unu
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Monoklonalna protutijela za pojedin
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Common acute lymphoblastic leukaemi
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Interakcijom s različitim efektors
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