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44. Viardot A, Moller P, Hogel J, et al. Clinicopathologic correlations of genomic gains and losses infollicular lymphoma. J Clin Oncol 2002;20:4523-30.45. Horsman DE, Connors JM, Pantzar T, Gascoyne RD. Analysis of secondary chromosomal alterationsin 165 cases of follicular lymphoma with t(14,18). Genes Chromosomes Cancer 2001;30:375-82.46. Hoglund M, Shen L, Connors JM, et al. Identification of cytogenetic subgroups and karyotypicpathways of clonal evolution in follicular lymphomas. Genes Chromosomes Cancer 2004;39:195-204.47. Küppers R. Prognosis in follicular lymphoma – it’s in the microenvironment. New J Med2004;351:2152-3.48. Dave SS, Wright G, Tan B, et al. Prediction of survival in follicular lymphoma based on molecularfeatures of tumor-infiltrating immune cells. N Engl J Med 2004;351:2159-69.49. Horning SJ, Rosenberg SA. The natural history of initially untreated low-grade non-Hodgkin’slymphoma. N Engl J Med 1984:311:1471-5.50. Rohatiner AZS, Lister TA. The clinical course of follicular lymphoma. Best Pract Res Clin Haematol2005;18:1-10.51. Plancarte F, Lopez-Guillermo A, Arenillas L, et al. Follicular lymphoma in early stages: high risk ofrelapse and usefulness of the Follicular Lymphoma International Prognostic Index to predict theoutcome of patients. Eur J Haematol 2006;76:58-63.52. Guo Y, Karube K, Kawano R, et al. Low-grade follicular lymphoma with t(14;18) presents ahomogeneous disease entity otherwise the rest comprises minor groups of heterogeneous diseaseentities with Bcl2 amplification, Bcl6 translocation or other gene aberrances. Leukemia 2005;19:1058-63.53. Schraders M, de Jong D, Kluin P, Groenen P, van Krieken H. Lack of bcl-2 expression in follicularlymphoma may be caused by mutations in the bcl2 gene or by absence of the t(14;18) translocation. JPathol 2005,205:329-35.54. Horsman DE, Okamoto I, Ludkovski O, et al. Follicular lymphoma lacking the t(14;18)(q32;q21):identification of two disease subtypes. Br J Haematol 2003;120:424-33.
55. Bosga-Bouwer AG, van Imhoff GW, Boonstra R, et al. Follicular lymphoma grade 3B includes 3cytogenetically defined subgroups with primary t(14;18), 3q27, or other translocations: t(14;18) and3q27 are mutually exclusive. Blood 2003;101:1149-54.56. Bartlett NL, Rizeq M, Dorfman RF, Halpern J, Horning SJ. Follicular large-cell lymphoma:intermediate or low grade? J Clin Oncol 1994;12:1349-57.57. Wendum D, Sebban C, Gaulard P. Follicular large-cell lymphoma treated with intensivechemotherapy: an analysis of 89 cases included in the LNH87 trial and comparison with the outcomeof diffuse large B-cell lymphoma. Groupe d'Etude des Lymphomes de I'Adulte. J Clin Oncol1997;15:1654-63.58. Rodriguez J, McLaughlin P, Hagemeister FB, et al. Follicular large cell lymphoma: an aggressivelymphoma that often presents with favorable prognostic features. Blood 1999;93:2202-7.59. Ott G, Katzenberger T, Lohr A, et al. Cytomorphologic, immunohistochemical, and cytogeneticprofiles of follicular lymphoma: 2 types of follicular lymphoma grade 3. Blood 2002;99:3806-12.60. Katzenberger T, Ott G, Klein T, Kalla J, Müller-Hermelink HK, Ott MM. Cytogenetic alterationsaffecting BCL6 are predominantly found in follicular lymphomas grade 3B with a diffuse large B-cellcomponent. Am J Pathol 2004;165:481-90.61. Bosga-Bouwer AG, van den Berg A, Haralambieva E, et al. Molecular, cytogenetic, andimmunophenotypic characterization of follicular lymphoma grade 3B; a separate entity or part of thespectrum of diffuse large B-cell lymphoma or follicular lymphoma? Hum Pathology 2006;37:528-33.62. Celis JE, Kruhoffer M, Gromova I, et al. Gene expression profiling: monitoring transcription andtranslation products using DNA microarrays and proteomics. FEBS Lett 2000;480:2-16.63. Brazma A, Vilo J. Gene expression data analysis. Minireview. FEBS Lett 2000;480:17-24.64. Staudt LM. Molecular diagnosis of the hematologic cancers. N Engl J Med 2003;348:1777-85.65. Alizadeh AA, Eisen MB, Davis RE, et al. Distinct types of diffuse large B-cell lymphoma identified bygene expression profiling. Nature 2000;403:503-11.
Page 1 and 2:
Središnja medicinska knjižnicaBor
Page 3 and 4:
Disertacija je izrađena u Odjelu z
Page 5 and 6:
3.4 Interfazna fluorescentna in sit
Page 7 and 8:
H&E - hemalaun & eozinHIV - virus h
Page 9 and 10:
klasifikacije limfoidnih neoplazmi
Page 11 and 12:
Folikularni limfom (FL) - 25% svih
Page 13 and 14:
simptoma. MPI obuhvaća dob bolesni
Page 15 and 16:
1.4 DNA microarray analiza genske e
Page 17 and 18:
molekularno različitih bolesti unu
Page 19 and 20:
Monoklonalna protutijela za pojedin
Page 21 and 22:
Common acute lymphoblastic leukaemi
Page 23 and 24: Interakcijom s različitim efektors
Page 25 and 26: između fenotipskih skupina i vrije
Page 27 and 28: BCL2 protein je eksprimiran u stani
Page 29 and 30: p53 protein se imunohistokemijski n
Page 31 and 32: 2. Ciljevi istraživanja1. U primar
Page 33 and 34: uključuje - MPI score 3 - veliki i
Page 35 and 36: 3.2 Tkivni microarrayUzorci s dovol
Page 37 and 38: fenotipom, a fenotipski uzorci CD10
Page 39 and 40: Slika 1. Shematski prikaz LSI IgH p
Page 41 and 42: 3.4.3 Analiza preparataKorišten je
Page 43 and 44: 4. Rezultati4.1.1 Fenotipske karakt
Page 45 and 46: Odnos imunofenotipskih skupina GCB
Page 47 and 48: U slučajevima bez t(14;18)(q32;q21
Page 49 and 50: 4.2 Usporedba proteinske ekspresije
Page 51 and 52: Usporedbom imunofenotipskih skupina
Page 53 and 54: 4.3 Usporedba utjecaja fenotipskih
Page 55 and 56: Međutim, imunofenotipske skupine G
Page 57 and 58: Uočena je statistički značajna r
Page 59 and 60: učestalost t(14;18)(q32;q21) u GCB
Page 61 and 62: iljega, MUM1/IRF4 i BCL6. Isto tako
Page 63 and 64: kriterija, prema današnjim spoznaj
Page 65 and 66: ekspresije gena koja bi imala za po
Page 67 and 68: 7. Sažetak73 bolesnika s povećani
Page 69 and 70: 8. Summary73 patients with lymph no
Page 71 and 72: 11. Morgensztern D, Lossos IS. Mole
Page 73: 33. Nanjangud G, Rao PH, Hegde A, e
Page 77 and 78: 78. Lossos IS, Alizadeh AA, Diehn M
Page 79 and 80: 100. Pescarmona E, De Sanctis V, Pi
Page 81 and 82: 122. Fabiani B, Delmer A, Lepage E,
Page 83 and 84: 143. Poulsen CB, Borup R, Nielsen F
Page 85 and 86: 166. Pinyol M, Hernandez L, Martine
Page 87 and 88: 189. Rubin MA, Dunn R, Strawderman
Page 89: Aktivno sam sudjelovala na 3 međun
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