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S94<br />

ments, even among countries where omnivorous diets<br />

are habitually consumed. For example, in UK mixed<br />

diets, iron is assumed to have a fixed bioavailability<br />

of 15%, irrespective of age and life-stage group [207],<br />

whereas in the <strong>United</strong> States and Canada, a factor of<br />

18% is used <strong>for</strong> the bioavailability of iron in the mixed<br />

diets of both children and nonpregnant adults, but 25%<br />

is used <strong>for</strong> women in the second and third trimesters<br />

of pregnancy and 10% <strong>for</strong> those consuming vegetarian<br />

diets [204]. Similarly, the <strong>United</strong> Kingdom uses a fixed<br />

factor of 30% <strong>for</strong> zinc, irrespective of age and life-stage<br />

group [207], but the <strong>United</strong> States and Canada apply<br />

a factor of 41% and 48% <strong>for</strong> the bioavailability of zinc<br />

from diets of adult (over 19 years) males and females,<br />

respectively, and 30% <strong>for</strong> preadolescent children [204].<br />

Australia and New Zealand have adopted the US and<br />

Canadian bioavailability adjustments <strong>for</strong> iron <strong>for</strong> children<br />

4 years of age or older, nonpregnant adults, and<br />

vegetarians, but the IZiNCG adjustments <strong>for</strong> zinc [36,<br />

208]. Other expert groups, such as FAO/WHO [181]<br />

and IZiNCG [36], employ several factors to adjust <strong>for</strong><br />

the bioavailability of iron and zinc, depending on the<br />

composition of the habitual diet, as noted earlier.<br />

References<br />

1. Hurrell R. Bioavailability—a time <strong>for</strong> reflection. Int J<br />

Vitam Nutr Res 2002;72:5–6.<br />

2. West CE, Eilander A, van Lieshout M. Consequences of<br />

revised estimates of carotenoid bioefficacy <strong>for</strong> <strong>dietary</strong><br />

control of vitamin A deficiency in developing countries.<br />

J Nutr 2002;132(9 suppl):2920S–6S.<br />

3. Cook JD, Dassenko SA, Lynch SR. Assessment of the<br />

role of nonheme-iron availability in iron balance. Am J<br />

Clin Nutr 1991;54:717–22.<br />

4. Tidehag P, Hallmans G, Wing K, Sjöström R, Ågren G,<br />

Lundin E, Zhang JX. A comparison of iron absorption<br />

from single meals and daily diets using radioFe ( 55 Fe,<br />

59 Fe). Br J Nutr 1996;75:281–9.<br />

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Clin Nutr 2003;77:1352–60.<br />

6. Institute of Medicine. Dietary reference intakes <strong>for</strong><br />

thiamin, riboflavin, niacin, vitamin B 6 , folate, vitamin<br />

B 12 , pantothenic acid, biotin, and choline. Washington,<br />

DC: National Academy Press, 1998.<br />

7. Schaafsma G. Bioavailability of calcium and magnesium.<br />

Eur J Clin Nutr 1997;51(suppl 1):S13–6.<br />

8. Stoecker B. Chromium. In: Bowman BA, Russell RM,<br />

eds. Present knowledge in nutrition. Washington, DC:<br />

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9. Gregory JF 3rd. Bioavailability of vitamin B 6 . Eur J Clin<br />

Nutr 1997;51:S43–8.<br />

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375–83.<br />

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Conclusions<br />

R. S. Gibson<br />

Adjustments are needed to translate physiological<br />

requirements into <strong>dietary</strong> requirements <strong>for</strong> certain<br />

nutrients, notably calcium, magnesium, iron, zinc,<br />

protein, folate, and vitamin A. The magnitude of the<br />

adjustments depends on the nutrient and will vary<br />

according to the nature of the habitual diet and a<br />

variety of host-related factors. However, in<strong>for</strong>mation<br />

on some of the host-related factors, especially those<br />

that influence the efficiency of luminal and mucosal<br />

digestion and absorption, is often limited, so that their<br />

effects on nutrient bioavailability are often ignored<br />

when setting <strong>dietary</strong> requirement estimates. At present,<br />

several algorithms have been developed to predict the<br />

bioavailability of iron, zinc, protein, folate, vitamin A,<br />

and carotenoids, but there is still no consensus among<br />

countries about which are the best algorithms to use.<br />

In some countries, fixed bioavailability factors are still<br />

used <strong>for</strong> certain nutrients, even though their efficiency<br />

of absorption may vary with the <strong>dietary</strong> level of the<br />

nutrient or the life-stage group.<br />

knowledge in nutrition. Washington, DC: International<br />

Life Sciences Institute, 2001:311–28.<br />

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<strong>for</strong>tification. Nutr Rev 1997;55:210–22.<br />

14. Solomons NW, Jacob RA, Pineda O, Viteri FE. Studies<br />

on the bioavailability of zinc in man. II. Absorption of<br />

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1979;94:335–43.<br />

15. Moser-Veillon PB, Mangels AR, Patterson KY, Veillon C.<br />

Utilization of two different chemical <strong>for</strong>ms of selenium<br />

during lactation using stable isotope tracers: An example<br />

of speciation in nutrition. Analyst 1992;117:559–62.<br />

16. Yeum KJ, Russell RM. Carotenoid bioavailability and<br />

bioconversion. Annu Rev Nutr 2002;22:483–504.<br />

17. McNulty H, Pentieva K. Folate bioavailability. Proc Nutr<br />

Soc 2004;63:529–36.<br />

18. Melse-Boonstra A, Verhoef P, West C. Quantifying folate<br />

bioavailability: A critical appraisal of methods. Curr<br />

Opin Clin Nutr Metab Care 2004;7:539–45.<br />

19. Sauberlich HE, Kretsch MJ, Skala JH, Johnson HL,<br />

Taylor PC. Folate requirement and metabolism in nonpregnant<br />

women. Am J Clin Nutr 1987;46:1016–28.<br />

20. Pfeiffer CM, Rogers LM, Bailey LB, Gregory JF 3rd.<br />

Absorption of folate from <strong>for</strong>tified cereal-grain products<br />

and of supplemental folate consumed with or without<br />

<strong>food</strong> determined by using a dual-label stable-isotope<br />

protocol. Am J Clin Nutr 1997;66:1388–97.<br />

21. van den Berg H, van den Gaag M, Hendriks H. Influence<br />

of lifestyle on vitamin bioavailability. Int J Vitamin Nutr<br />

Res 2001; 72:53–9.<br />

22. Gregory JF 3rd. Bioavailability of thiamin. Eur J Clin<br />

Nutr 1997;51(suppl 1):S34–7.<br />

23. Castenmiller JJM, West CE. Bioavailability and biocon-

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