Nutritional Secondary Hyperparathyroidism in the Horse

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52 Experimental Nutritional Secondary 1 lyperp~rathyroi~lisin in the IHorsc . . . v) Increase; serum phosphorus still increasing and hypocalcemia partly compensated for. vi) Decrease; hyperphosphatemia compensated for to a greater degree than hypocalcemia (with the exception of NSH 2). The regression lines described similar diphasic increase-decrease changes in all NSH horses. The magnitude and time periods were somewhat different in the horses, however. It should be emphasized that the increase-demase phases in ser/cnl alkaline phosphatase were inverse4 related to the conti;rliioiu chanqes in semiin calciiiyN. 3. Roentgenologic Observations A . Intrauital' Exaininatioii The results of the series of radiographs taken during the course of the experiment are summarized in Table XVIII. Progressive radio- lucency was evident in the mandibles (Fig. 18) and maxillae. Rc- companied by this, a radiolucent miliary mottling which might also be described as a spongy or moth-eaten appearance developed. Pro- gressive loss of the laminae durae was seen. Subperiosteal resorption appeared in the ventrodorsal views of the mandible on thecortical bone lateral to the roots of the corner incisor teeth. The characteristic changes in the metacarpi were endosteal roughening, radiolucent linear stria- tions in the cortex, and coarse trabeculation of the spongy bone at the metaphyseal ends of the medullary cavity. The changes in the mandibles and maxillae were observed sooner and progressed at a more rapid rate than those in the metacarpus. Although the changes noted in the affected colts were identical, the rates of change varied. NSH 2 showed the earliest change, NSJ-I 3 next, and then NSI-I 1. The degree of change in NSH 1 was less than that in NSH 2 or 3. It must be noted that the changes were insidious and progressive, so that they did not become strikingly apparent from one month to the next. However, when 4 or 5 monthly radiographs were reviewed, the changes were obvious. Downloaded from vet.sagepub.com by guest on April 14, 2010
Rocntgencilogic Observations 53 Fie. 18. Ante-mortcin vcntrodorsal view of rostra1 end of inaiidihlc of control colt on right (u~cclc 28; age 14 months) and of NSH 3 on lcft (u,cck 40, age 16 months). Note lack (if dcvclopmcnt of laminae durac dcntcs around pcrinancnt central incisor of N S1 I 3 compared to control (arrou.) ; cndostcxl resorption and thinning of cortex in NSI I 3; loss of trahcculation and gcncralizcdradicilucciicy iiiNSH3. 7 ahie XI ZZt. Expcrimcntal nutritional secondary hypcrparathyroidism in horses : R~~cntgeiiographic changes Wcck 6 11 16 21 25 30 34 39 41 Radioluccticy and tniliary Enciostcal roughening and linear mottling of mandiblc and radioluccnt striaticin in cortex of mas illa metacarpus NSI-I horse 110. NSI-I horse no. 1 2 3 (:ontiol 1 2 3 Control - no change; * milcl change; *j: nioclcratc change; *':* sc\~cxc changc. Downloaded from vet.sagepub.com by guest on April 14, 2010
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Pathologia Veterinaria Online http:
Page 3 and 4:
Supplementum ad Vol. 1 (1964) Patho
Page 5 and 6:
V . Experimental Nritritional Secon
Page 7 and 8: Introduction and Object of Investig
Page 9 and 10: I. The Anatomy of the Parathyroid G
Page 11 and 12: Comparative Aspects of the Embryolo
Page 13 and 14: The Aracroscopic Anatomy of the Equ
Page 15 and 16: The Microscopic Anatomy of the Equi
Page 17 and 18: 'I'hc hlicroscopic Anatomy of the E
Page 19 and 20: ’The I\licroscopic Anatomy of the
Page 21 and 22: 10 . 9 . a . 7 0 + 6 . 5 . 0 ’I
Page 23 and 24: ‘The hl icroscopic Anatomy of the
Page 25 and 26: ’I’hc hlicroscopic Anatomy of t
Page 27 and 28: ‘I’lic ihlrcroscopic Anatomy of
Page 29 and 30: ‘I’hc Alicroscopic Anatomy of t
Page 31 and 32: Discussion 25 7bbic 1 .. Avcragc si
Page 33 and 34: Discussion 27 Table VZZ. Nuclear si
Page 35 and 36: 11. Nutritional Secondary Hyperpara
Page 37 and 38: The Nature of the Osteopathy 31 Fig
Page 39 and 40: ’The Nature of the Osteopathy 33
Page 41 and 42: Etiology 35 Experiments and clinica
Page 43 and 44: Clinical Pathology 37 Table X. Seru
Page 45 and 46: 111. Experimental Nutritional Secon
Page 47 and 48: Ration 41 Table XI/. Calcium and ph
Page 49 and 50: Necrops y 43 6. Necropsy The animal
Page 51 and 52: Clinical Observations 45 During wee
Page 53 and 54: Clinico-pathologic Determinations 4
Page 55 and 56: 90. *. 90. 90. 70. / . Clinico-path
Page 57: (:linico-pathologic Determinations
Page 61 and 62: lioentgcnologic Ohscrvntions 55 I,'
Page 63 and 64: Pathologic Anatomy 57 7bb/e XIS. Si
Page 65 and 66: Pathologic Anatomy 59 fhb/c. A’X.
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Page 71 and 72: Pathologic Anatoiny Downloaded from
Page 73 and 74: Pathologic Anatomy 67 Downloaded fr
Page 75 and 76: Pathologic Anatomy 69 Fiq. 37. Cont
Page 77 and 78: V. Experimental Nutritional Seconda
Page 79 and 80: Scruin Phosphorus, Calciiiiii, and
Page 81 and 82: Serum Phosphorus, Calcium, and Alka
Page 83 and 84: Serum Phosphorus, Calcium, and Alka
Page 85 and 86: The Parathyroid Glands 79 should be
Page 87 and 88: The Skeleton 81 5. The Skeleton The
Page 89 and 90: The Skeleton 83 ary hyperparathyroi
Page 91 and 92: Summary and Conclusions The thesis
Page 93 and 94: Siimmary and Conclusions 87 Rocntgc
Page 95 and 96: References 89 COILIP, J. B.: 'I'hc
Page 97 and 98: Refereiices 91 ~~CILAN, F. C. and U
Page 99 and 100: Appendix Tables and Statistical Ana
Page 101 and 102: Tables and Statistical Analyses 95
Page 103 and 104: ’Tablcs and Statistical Analyscs
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Nutritional Secondary Hyperparathyroidism in the Horse

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