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BIMM118
Targets of cAMP:
Protein Kinase A (PKA):
– Consists of four subunits: two regulatory
and two catalytic subunits => after cAMP
binding to the regulatory subunits the
catalytic subunits dissociate and
translocate to the target substrates.
Cyclic Nucleotides
– First identified process regulated by PKA
was glycogenolysis (PKA phosphorylates
glycogen phosphorylase kinase which in
turn activates glycogen phosphorylase.
PKA also phosphorylates and inactivates
glycogen synthase => release of glucose)