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BIMM118
Signaling through Adapter proteins:
Growth Factor Receptors
• grb2: adapter with one SH2 domain which binds PY
residue on RTK, and two SH3 domains which bind to
• Sos: “Son of Sevenless” (mutation in drosophila
prevents development of the R7 photoreceptor cell).
Functions as a GEF to facilitate GTP loading of
• ras: GTP binding protein, farnesylated; protooncogene,
provides a docking site on the plasma membrane for raf.
• ras-GAP: negative regulator of groth factor signaling:
promotes GTP hydrolysis through the GTPase activity of
ras.