color pdf

BIMM118
Signal Transduction:
Cytokine Receptors
Receptors lack intrinsic catalytic activity but associate w/ cytosolic enzymes
STAT: Signal transducer and activator of transcription
– contain SH2 domains
– become tyrosine phosphorylated after stimulation
– 6 family members
– homo or heterodimerize
– translocate to nucleus and bind enhancers
JAK: Janus kinase
– large cytoplasmic tyrosine kinases (130-140 kDa)
– NO SH2 or SH3 domains
– kinase-like domain