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BIMM118
Sympathomimetics
Non-selective agonists:
• Epinephrine (Adrenaline)
Adrenergic System - Agonists
– Activates both α and β receptors;
– Blood pressure increase, but effect on systolic pressure dominant
– Dilates bronchii
– Potent vasopressor => Clinical uses limited
– Used for:
symptomatic treatment of anaphylactic shock (Epi-Pen®)
adjuvant in local anesthetics (increases duration, reduces bleeding)
• Norepinephrine (Noradrenaline)
– Activates mostly α receptors => systolic and diastolic blood pressure increase
– Very potent vasopressor => Clinical uses limited to severe shock treatment