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BIMM118
Growth Factor Receptors
• Three subclasses:
– Class I: two Cys-rich region in the EC, monomeric ligand
EGF-R, erbB2, erbB3, erbB4 (heregulin receptors)
– Class II: heterotetrameric: 2 α and 2 β chains stabilized through S-S bonds: monomeric ligand
Insulin-R, IGF-1-R
– Class III: Repeats of mmunoglobulin-like structure, dimeric ligand
FGF-R, NGF-R, PDGF-R, CSF-1-R, c-kit