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BIMM118
Drug Distribution
Volume of Distribution (V d ) [ml or l]:
= Amount of drug in the body [mg] / drug concentration plasma [mg/ml]
• V d is an apparent volume (volume that the drug must be distributed
in to produce measured plasma concentration
• Drug with near complete restriction to plasma compartment would
have V d = plasma volume (.04 L/kg) = 2.8 L/70 kg patient
• But: Many drugs are highly tissue bound => large V d
e.g. Chloroquine: V d = 13,000 L