color pdf

BIMM118
Signal Transduction:
SMADs:
Ser/Thr-kinase Receptors
– 8 members - conserved MH1 and MH2 domain
– rapidly phosphorylated in response to TGFβ (2,3) or
BMP (1,5,8)
– Smads function in heteromeric complexes
– “common” Smad = Smad-4 (Smad-4 required for all
Smad signaling)
– translocate to the nucleus
– phosphorylated by the receptor itself
– phosphorylation motif: SSXS
– Smad1 potentially also activated by MAPK
– Mutations of Smads and /or TGFβR are found in 90%
of colon cancers