p-Tert-Butylphenol - UNEP Chemicals

OECD SIDS P-TERT-BUTYLPHENOL
(b)
Type: LD0 [ ]; LD100 [ ]; LD50 [X]; LDL0 [ ]; Other [ ]
Species/strain: Sprague-Dawley rat
Value: male: 5,360 mg/kg b.w.
female: 3,620 mg/kg b.w.
Method: Other
GLP: Yes [ ] No [X] ? [ ]
Test substance: purity: 99 %
Remarks: p-t-Butylphenol was treated by stomach intubation at 2,500, 3,500, 5,000
mg/kg and 10,000 mg/kg (males only) as a 25 % (w/v) suspension in corn
oil.
Sluggishness, unsteady gait, prostration, unkempt appearance, and nasal
discharge were observed as the principal signs of toxicity. Signs of toxicity
subsided in survivors at 3 to 7 days after dosing. Deaths were induced from
2 hours to 5 days after dosing. In rats died during the study, there were
mottling of the lungs and livers as the principal macroscopic lesions in
female but no significant gross lesions in male.
Reference: Klonne et al.: 1988
(c)
Type: LD0 [ ]; LD100 [ ]; LD50 [X]; LDL0 [ ]; Other [ ]
Species/strain: Rat
Value: 2,990 mg/kg b.w.
Method: Other
GLP: Yes [ ] No [X] ? [ ]
Test substance: purity: unknown
Remarks:
Reference: Smyth et al.: 1969
(d)
Type: LD0 [ ]; LD100 [ ]; LD50 [X]; LDL0 [ ]; Other [ ]
Species/strain: Rat
Value: ca. 3,500 mg/kg b.w.
Method: Other (BASF-Test)
GLP: Yes [ ] No [ ] ? [X]
Test substance: purity: unknown
Remarks:
Reference: BASF AG: 1971
(e)
Type: LD0 [X]; LD100 [ ]; LD50 [ ]; LDL0 [ ]; Other [ ]
Species/strain: Guinea pig
Value: 400 mg/kg b.w.
Method: Other
GLP: Yes [ ] No [ ] ? [X]
Test substance: purity: 99 %
Remarks: The 100 % lethal dose was found to be greater than 1,400 mg/kg and
probably 2,000 mg/kg.
Reference: The Dow Chemical Company: 1997a
5.1.2 ACUTE INHALATION TOXICITY
(a)
Type: LC0 [X]; LC100 [ ]; LC50 [ ]; LCL0 [ ]; Other [ ]
UNEP Publications 103