p-Tert-Butylphenol - UNEP Chemicals

OECD SIDS P-TERT-BUTYLPHENOL
(e)
Type: Depigmentation test
Results: p-t-Butylphenol (10 mg/kg/day) in peach oil was injected intramuscularly
to black rabbits (no data on the number of used animals) daily for 6 weeks.
20 - 24 days after the beginning of the treatment, small areas of grey hair
were observed on the flanks and backs of the animals. In four rabbits, there
was a spastic paralysis of the hind legs.
Remarks: In four rabbits, inhalation exposure to formaldehyde vapour was performed
together with the above treatment, but there was no effect on the greying.
Reference: Malten et al.: 1971
(f)
Type: Depigmentation test
Results: 0.5 % p-t-butylphenol (7.5 mg/kg) in ol. persicarium was injected
intramuscularly to eight black rabbits (no data on exposure period). On the
other hands, four other rabbits were given their fodder containing this
chemical of the same amount. 12 – 20 days after the beginning of the
treatment, an apparent greying was observed without previous browning. 2
years after the end of the treatment, grey hair still remained in 3/8 animals
injected intramuscularly. Between two routes of the treatment, there were
no differences in the effects of this chemical.
Remarks:
Reference: Malten et al.: 1971
(g)
Type: Depigmentation test
Results: Emulsions was made of 9 g of emulgide in 1,000 ml water, to which 600 mg
of p-t-butylphenol was added during mixing. This emulsions, equal to 7.5
mg/kg b.w., was treated to 10 wild coloured guinea pigs by gavage 5 days
per week for 10 months. Several animals died, due to well known
difficulties with tube feeding. Clear-cut depigmentation was not observed
within the limits of accuracy of judging depigmentation even with colour
photographs.
Remarks:
Reference: Malten et al.: 1971
(h)
Type: Depigmentation test
Results: 0.1 ml aliquot of p-t-butylphenol was applied to adult black guinea pigs on
the dorsal epilated surface (eight sites, 3 cm x 3 cm), and the unepilated skin
of ears and nipples. Various solvent was used such as DMSO, acetone and
hydrophilic ointment, and the concentration of this chemical ranged from
0.01 M to 1.0 M for various liquid solvents and from 0.1 % to 10 % for solid
ointment bases. p-t-Butylphenol induced definite, but moderate
depigmentation (uniform hypopigmentation) on the back and ear, but not on
nipple. Minimal eliciting concentration was 0.25 M in DMSO and 10 % in
hydrophilic ointment on the back, and 0.25 M in DMSO on the ear. Minimal
time for the appearance of maximum depigmentation was 23 days after
applications of 0.25 M in DMSO on the back and the ear. The longest time
required to induce maximal depigmentation was 112 days for 1 M in acetone
on the back.
In addition, this chemical induced severe and moderate irritation to the skin
of the back and the ear, respectively.
UNEP Publications 119