p-Tert-Butylphenol - UNEP Chemicals

OECD SIDS P-TERT-BUTYLPHENOL
(b)
Type: LD0 [X]; LD100 [ ]; LD 50 [ ]; LDL0 [ ]; Other [ ]
Species/strain: New Zealand white rabbit
Value: 16,000 mg/kg b.w.
Method: Other
GLP: Yes [ ] No [X] ? [ ]
Test substance: purity: 99 %
Remarks: Ground p-t-butylphenol, which was moistened with distilled water, was
applied to the clipped skin of the trunk at 2,000, 8,000, 16,000 mg/kg and
covered with Vetrap (3M) Bandaging Tape.
Signs of severe skin irritation (erythema, edema, fissuring, desquamation
and/or necrosis) were observed in both sexes of all groups. However, the
sign of toxicity was only prostration in one female at 12,000 mg/kg and no
significant lesions were observed at necropsy.
Reference: Klonne et al.: 1988
(c)
Type: LD0 [ ]; LD100 [ ]; LD 50 [ ]; LDL0 [ ]; Other [X]
Species/strain: Rabbit
Value: See remarks
Method: Other
GLP: Yes [ ] No [ ] ? [X]
Test substance: a mixture of 66.3 % p-t-butylphenol, 13.4 % o-t-butylphenol, 19.8 % phenol
and 0.5 % di-t-butylphenol
Remarks: The subject material as a 50 % solution in ethanol was applied to the clipped
bellies of rabbits restrained on animal boards. An hour later, the animals
were released, bandaged so that they could not lick themselves, and returned
to their respective cages.
At a dose of 3,000 mg/kg, tremors were caused in 15 minutes, which were
typical change of phenol poisoning. In addition, in 1.5 hours after the
application, severe burning of the skin and death was observed. At a dose of
1,000 mg/kg, tremors were also caused and severe burning was observed.
The animals survived for 24 hours. At a dose of 300 mg/kg, severe burns
were only observed and all animals survived.
Reference: The Dow Chemical Company: 1997b
(d)
Type: LD0 [ ]; LD100 [ ]; LD 50 [ ]; LDL0 [ ]; Other [X]
Species/strain: Guinea pig
Value: See Remarks
Method: Other
GLP: Yes [ ] No [ ] ? [X]
Test substance: purity: 99 %
Remarks: A single dose of 10 % solutions in olive oil and in alcohol was applied to
the clipped bellies of guinea pigs. With the olive oil solution, no death was
induced at doses of up to and including 2,000 mg/kg. While one of 5
animals died from doses of 2,000 mg/kg and 3,000 mg/kg when alcoholic
solution was used as solvent.
Reference: The Dow Chemical Company: 1997a
5.1.4 ACUTE TOXICITY, OTHER ROUTES OF ADMINISTRATION
UNEP Publications 105