p-Tert-Butylphenol - UNEP Chemicals

OECD SIDS P-TERT-BUTYLPHENOL
124
(e)
Type: Patch Test
Results: Sensitizing [ ]; Not sensitizing [X]; Ambiguous [ ]
Classification: Sensitizing [ ]; Not sensitizing [ ]
Method: Other
GLP: Yes [ ] No [ ] ? [X]
Test substance: purity: unknown
Remarks: Two patients with contact dermatitis reacting positively to p-t-butylphenolformaldehyde
resins in a patch test showed a negative reaction to 2 % p-tbutylphenol
in petrolatum.
Reference: Bruze et al.: 1985
(f)
Type: Patch Test
Results: Sensitizing [ ]; Not sensitizing [X]; Ambiguous [ ]
Classification: Sensitizing [ ]; Not sensitizing [ ]
Method: Other
GLP: Yes [ ] No [ ] ? [X]
Test substance: purity: unknown
Remarks: Three patients with vitiligo occupationally exposed to p-t-butylphenol
showed negative reactions to 0.01, 0.05, 0.1 and 0.5 % test substance in 70 %
ethanol and vaseline. Tests were read at 48 hours, 72 hours and 14 days.
Reference: Budde & Stary: 1988
B. Toxicokinetics and toxicodynamics
(a)
Results: Urine samples of workers engaged in packing of p-t-butylphenol (bagging,
weighing and sealing of the bags) were collected for 24 h after the start of
each shift. Acid-hydrolyzed samples were analyzed by GC. Mean level in
urine was 4.20 µg/ml at day shift and 6.12 µg/ml at night shift. Mean total
urinary excretion (24 h) was 2.31 mg, estimated respiratory absorption
(during substantial working time; workers were wearing respirators) was
0.74 mg, and 8 h-TWA (time weighted average value for workers ambient
air) was 0.39 mg/m 3 . p-t-Butylphenol was even qualitatively detected by
GC in an diethyl ether extract of acid-hydrolyzed sweat collected from the
back of workers immediately after bathing. In contrast to the urine
samples, no free p-t-butylphenol could be detected (Japan, not dated).
Remarks:
Reference: Kosaka et al.: 1989
(b)
Results: Urine samples of male workers engaged in the production of p-tbutylphenol
were collected during shift and during the half-a-day period
after the shift. Mean concentrations were from 0.5 µg/ml (engineers) to 6.3
µg/ml (product packers). After introduction of semi-automatization of
weighing and bag sealing, and installation of mighty local exhaust systems,
concentration in urine samples decreased to a range from traces (engineers)
to 2.2 µg/ml (product packers). In another factory with semiautomatization,
non-detectable amounts to traces were found in the urine of
plant operators and 1.55 - 3.34 µg/ml were found in urine of 3 product
packers (time averages). The biological half-life of p-t-butylphenol in urine
taken from these 3 examinees was calculated to be 4 h on average. (Japan,
not dated)
UNEP Publications