p-Tert-Butylphenol - UNEP Chemicals
p-Tert-Butylphenol - UNEP Chemicals
p-Tert-Butylphenol - UNEP Chemicals
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OECD SIDS P-TERT-BUTYLPHENOL<br />
Precipitation conc:<br />
Genotoxic effects: + ? -<br />
With metabolic activation: [ ] [ ] [X]<br />
Without metabolic activation: [ ] [ ] [X]<br />
Method: Guidelines for Screening Mutagenicity Testing of <strong>Chemicals</strong> Japan, and<br />
OECD TG (471 and 472)<br />
GLP: Yes [X] No [ ] ? [ ]<br />
Test substance: purity: 99.9%<br />
Remarks:<br />
Reference: MHW, Japan: 1996<br />
(b)<br />
Type: Bacterial gene mutation assay<br />
System of testing: S. typhimurium TA1535, TA1537, TA98, TA100<br />
E. coli WP2 uvrA¯<br />
Test method:<br />
Solvent: Dimethyl sulfoxide<br />
Dose: 1.6, 8, 40, 200, 1,000 µg/ml<br />
Metabolic activation: With [ ]; Without [ ]; With and Without [X]; No data [ ]<br />
Results:<br />
Cytotoxicity conc: With metabolic activation: 1,000 µg/ml (all strains)<br />
Without metabolic activation: 1,000 µg/ml (all strains)<br />
Precipitation conc:<br />
Genotoxic effects: + ? -<br />
With metabolic activation: [ ] [ ] [X]<br />
Without metabolic activation: [ ] [ ] [X]<br />
Method: Guidelines for bacterial mutagenicity testing published by the major Japanese<br />
Regulatory Authorities including MITI, MHW, MOL and MAFF<br />
GLP: Yes [X] No [ ] ? [ ]<br />
Except that the concentration, homogeneity and stability of test material<br />
preparations were not determined by analysis and that this specific study may<br />
not have been subject to procedure inspection by the Quality Assurance Unit<br />
Test substance: purity: unknown<br />
Remarks: Positive control:<br />
With metabolic activation:<br />
2-Aminoanthracene at 2 µg/plate for TA 1535 and 10 µg/plate<br />
for WP2 uvrA¯<br />
Benzo(a)pyrene at 5 µg/plate for TA 100, TA1537 and TA 98<br />
Without metabolic activation:<br />
N-ethyl-N’-nitro-N-nitrosoguanidine at 2 µg/plate for WP2<br />
uvrA¯, 3 µg/plate for TA100 and 8 µg/plate for TA 1535<br />
9-Aminoacridine at 80 µg/plate for TA 1537<br />
4-Nitroquinoline-1-oxide at 0.2 µg/plate for TA 98<br />
Reference: Safepharm Laboratories Ltd.: 1992a<br />
(c)<br />
Type: Bacterial gene mutation assay<br />
System of testing: S. typhimurium TA1535, TA1537, TA1538, TA98, TA100, E. coli WP2,<br />
WP2 uvrA, S. cerevisiae JD1<br />
Test method:<br />
Solvent: Dimethyl sulfoxide or Hexane<br />
Dose: Up to 5.0 mg/ml<br />
Metabolic activation: With [ ]; Without [ ]; With and Without [X]; No data [ ]<br />
Results:<br />
Cytotoxicity conc: With metabolic activation:<br />
<strong>UNEP</strong> Publications 113
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