p-Tert-Butylphenol - UNEP Chemicals
p-Tert-Butylphenol - UNEP Chemicals
p-Tert-Butylphenol - UNEP Chemicals
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OECD SIDS P-TERT-BUTYLPHENOL<br />
+S9 (20-hour cultures): 1.88 –120 µg/ml<br />
+S9 (30-hour cultures): 1.88 – 60 µg/ml<br />
S-9: Rat liver, induced with Aroclor 1254<br />
Metabolic activation: With [ ]; Without [ ]; With and Without [X]; No data [ ]<br />
Plates/test: 2<br />
Results:<br />
Cytotoxicity conc: With metabolic activation: 60.0 µg/ml and more dose<br />
(20- and 30-hour cultures)<br />
Without metabolic activation: 30.0 µg/ml and more dose<br />
Precipitation conc:<br />
Genotoxic effects: clastogenicity polyploidy<br />
+ ? - + ? -<br />
With metabolic activation: [ ] [ ] [X] [ ] [ ] [X]<br />
Without metabolic activation: [ ] [ ] [X] [ ] [ ] [X]<br />
Method: OECD Guidelines for Testing of <strong>Chemicals</strong> (1981) No. 473 “Genetic<br />
Toxicology: Chromosome Aberration Test” and Method B10 of Commission<br />
Directive 84/449/EEC<br />
GLP: Yes [X] No [ ] ? [ ]<br />
Except that the concentration, homogeneity and stability of test material<br />
preparations were not determined by analysis and that this specific study may<br />
not have been subject to procedure inspection by the Quality Assurance Unit<br />
Test substance: purity: unknown<br />
Remarks:<br />
Reference: Safepharm Laboratories Ltd.: 1992b<br />
(c)<br />
Type: Chromosomal aberration test<br />
Type of cells used: Rat liver epithelial-type cells<br />
Test method: Other<br />
Solvent: Dimethyl sulfoxide<br />
Dose: Up to 0.5 mg/ml GI50 (50 % growth inhibition dose)<br />
Metabolic activation: With [ ]; Without [X]; With and Without [ ]; No data [ ]<br />
Results:<br />
Cytotoxicity conc: With metabolic activation:<br />
Without metabolic activation:<br />
Precipitation conc:<br />
Genotoxic effects: clastogenicity<br />
+ ? -<br />
Without metabolic activation: [ ] [ ] [X]<br />
Method: Other<br />
GLP: Yes [ ] No [ ] ? [X]<br />
Test substance: purity: > 95 %<br />
Remarks: The cells were treated for 24 hr and 100 cells were analyzed microscopically.<br />
As for polyploidy, it is not mentioned<br />
Reference: Dean et al.: 1985<br />
(d)<br />
Type: Mutation of L5178Y mouse lymphoma cells at the thymidine kinase TK +/-<br />
locus. Fluctuation assay<br />
Type of cells used: L5178Y mouse lymphoma cells (heterozygous at the thymidine kinase locus)<br />
Test method:<br />
Solvent: Dimethylsulfoxide<br />
Positive control: -S9: Ethyl methanesulphonate at 931.5 µg/ml<br />
+S9: Cyclophosphamide at 5 µg/ml<br />
Dose: 5.0, 10.0, 20, 40, 80 µg/ml<br />
<strong>UNEP</strong> Publications 115
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