p-Tert-Butylphenol - UNEP Chemicals

OECD SIDS P-TERT-BUTYLPHENOL
118
Reference: MHW, Japan: 1996
*5.9 DEVELOPMENTAL TOXICITY/ TERATOGENICITY
No data are available.
5.10 OTHER RELEVANT INFORMATION
A. Specific toxicities
(a)
Type: Depigmentation test
Results: 0.1 ml solution was applied daily to 9 cm 2 of the shaved skin of 12 male and
female black guinea pigs for up to three weeks.
5 mg in acetone (5 %): mildly irritating; no depigmentation
10 mg in acetone (10 %): strongly irritating (erythema and edema
extending beyond area of application); no
depigmentation
10 mg in DMSO (10 %): moderate irritating; strong depigmentation
potency
10 mg in propylene glycol (10 %): moderate irritating; strong depigmentation
potency
1 mg in any vehicle caused no irritation.
Remarks: Observation period was 3 months.
Reference: Gellin et al.: 1970
(b)
Type: Depigmentation test
Results: 0.2 mL olive oil, to which 0.2 M of p-t-butylphenol was added, was
administered orally to black C 57 male mice 3 times a week for 6 months.
Diffuse or patchy depigmentation was observed in the majority of the
animals.
Remarks:
Reference: Hara: 1967, Hara and Nakajima: 1969
(c)
Type: Depigmentation test
Results: 0.05 mL olive oil, to which 0.01 M of p-t-butylphenol was added, was
injected subcutaneously to black C 57 male mice 6 times a week for 7
months. 12 weeks after the beginning of the injection, depigmentation was
observed.
Remarks:
Reference: Hara and Uda: 1966, Hara and Nakajima: 1969
(d)
Type: Depigmentation test
Results: Vitiligo-like depigmentation of black mice was achieved as much by
ingestion as by inhalation of p-t-butylphenol. Cutaneous application in
different solvents and at different concentrations did not elicit any skin
changes. A modified Kligman solution (p-t-butylphenol, vitamin A acid
and dexamethasone) caused distinct depigmentation (no further data
available).
Remarks:
Reference: Forck et al.: 1981
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