p-Tert-Butylphenol - UNEP Chemicals

OECD SIDS P-TERT-BUTYLPHENOL
B. Toxicodynamics, toxicokinetics
122
(a)
Type: Metabolism
14
Results:
C-labelled p-t-butylphenol was given intravenously to male Wistar rats at
a single dose of 1.2 - 10.4 mg/kg b.w. Subsequently, bile and urine was
collected for 4 hours. 65 - 71 % and 17 - 21 % of the applied dose were
excreted as glucuronide conjugate and sulfate conjugate, respectively (total
recovery of radioactivity: 91 - 93 %). The ratio of glucuronidation and
sulfation was not dose-dependent.
Remarks: D-Mannitol was infused to stimulate diuresis during the experiment. 14 Clabelled
p-t-butylphenol dissolved in saline at pH 10.5 before dilution to
the required concentration with saline.
In vitro incubation of isolated hepatocytes with 3.6 - 120.2 mg/l at 37
degree C for 1 hour supported these results concerning the ratio of
conjugates and dose-dependency.
Reference: Koster et al.: 1981
(b)
Type: Metabolism
Results: [U- 14 C]p-t-butylphenol was given intravenously to rats at a dose of 18
mg/kg b.w.. Urine and bile were collected during 24 hr and analyzed by
thin layer chromatography. 1.5 ± 0.2 µmol was excreted as sulfate in the
urine, while no significant amounts were found in the biliary excretes.
Remarks:
Reference: Nanbo: 1991
(c)
Type: Metabolism
Results: In vitro incubation of 112.65 mg [U- 14 C]p-t-butylphenol with rat liver
cytosol at 37 degree C for 1 h yielded 65.5 +/- 11.8 nmol/min/mg protein-1
of sulfated TS.
Remarks:
Reference: Nanbo: 1991
(d)
Type: Distribution and Excretion
14
Results:
C-labelled p-t-butylphenol (147 µg/kg/day) in Keltrol solution was
administered to male Wistar rats by gavage daily for 3 days. Urine and
feces were collected daily. 26.7 % and 72.9 % of the applied dose was
eliminated via feces and urine, respectively. Distribution in tissues and
organs was as follows: retention in abdominal adipose tissue: not
detectable (< 0.01 %/g), liver: 0.02 %, lung: not detectable (< 0.01 %),
carcass: 0.1 % (data in percent of the applied doses)
Remarks: Post observation period was 4 days.
Reference: Freitag et al.: 1982
* 5.11 EXPERIENCE WITH HUMAN EXPOSURE
A. Skin sensitization
(a)
Type: Patch Test
Results: Sensitizing [X]; Not sensitizing [ ]; Ambiguous [ ] *See Remarks
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