The EffĘcts of In Partial 3ėĄLfil1n€nt of Tle B€qüireûents for Eh ...

GÊOüP V the group sÍtå bilateraJ. electrolytj.c lesioÐ
j-n the f rigla l_-gelg__.llFlL)
A,Genera I obs€rv ati-Õ¡:
ss it this group exhil¡ited sinilar general pattêrü
of t,ehaviour prior to and sutrsêquent io the lesioning"
Àüj-mals shorreå ro spêcific signs of hyperre- act.ivity t.a
human trandling" Ull1ike the 5-ç i:l the fi çÐ group, they
öiå nct slcr strcng startlê reaction rhÈn a puff of aj.r
nas blolr¡ into the cagÈ.
Ð. acttsj.ty 'in the rotationãl ruaniÊg sheêI:
Figure 411 sboss that, as compareå to thê pre-
operativ.e 1eve1 and the activiiy 1êvel cf the shan
I€sionËd grcl¡F,the fiontal ss sho¡{ed an increase ir¡ the
f.irst thre€ Fast- lêsioned testing sessio¡s. The activi-
ty levêl rêtursed to the sane general l_èvêl by the 4th
post-l-€sioü€d t€sting sessicn.The €ffect of 2.5 ng/kg of
d-anphetaniae cn the fraÐtal aai$als wer€ stüdåed as a
pharmacological t verificat¡.Il. cf the lesion síte. Íh€
êflêct oÈ th€ ilrug rras nèasür€d it t.l¡e activity running
.tr êe1 at 10 mi¡ute intêrvaf fcr 10û nj-nutes after ip
injecticn af the d!ug. Às sholrn iIl figure 45, the
frontal ss disFlay€d the drüb1ê peak eff,sct ol the
drug,flhåch is r:nigue to th€ lrontal lesioned a¡isìals
{.I versèn,l-9?1,t ynch,1969} ,
125