The EffĘcts of In Partial 3ėĄLfil1n€nt of Tle B€qüireûents for Eh ...

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D€adryl-€r a d ¡iyexs { 19?0 I st died the effects of interp.låi-€d septal and casdate stinulation ûn ÐRI, per- formarce i¡ al-þinô xats ( 197A1 , lrith a vies tÕ tleternine th€ pcilt xithi¡ tàe ¿lelay íît€rvãl ch€re stiDu.lation of eithër structu.re naxåna]1y istlilêncês DRf perfordanc€, The experímênt ccnsisted of six daily sessioãs to ¿ach of three i terpclat€d sti¡rulatic¡ coniliti-o¡s. thê thxèe interresponse tj.më cl-asses s€r€ : the earJ-y {0 - 4.3 sec.) thê !Ìiddle {4,4 - 8"7 sec. } and th€ lat€ {11.0 - 15.4 s€c") intêrresporse titse. DaiJ-y sessions consisted of foûr count€r.bal-ancêd blccks rf 18 reinforcêne¡ts. The sÈj-û¿latiag parame+,ers lder€ 60 1r/2 ns ,/sêc of 20 - 100 Dj-crcanFs for thè septal 5s aÐd 3"C 1/2 ¡ìs/sec at ?û0 ûicf,oanps fcE the caudate Ss. flhi1€ the substaBt iaL clifference iI¡ stj.nìl1ation íntÊnsiÈies cloud thè inÈ€rprê- tation of the Eesults, the r€sults are in part consistart rith cthêr stüaliês { Bucbsa.ld Ët al ,L964 i Büser et al_ , 1961¡ ) " Speciïical-1y, f,csuLts shoyed that. sith septal stinulaticn f aci.Ij,tation of r€spoflse inhibìtion in the tearl:rt and rlatet tine class€s of thê DHL delay intêrval did not eühance overall Ð81 p€rfornarìc€. ¡¡either äid it significantLy disrBpt normal- tinilg behaviouf, inalicating that such stinüLatic¡ did nct act as a re1'ersible lêsi.o!. i ith cauilate aninals, cn the oth€r haad, t.hêx€ r¡as a sig$if j.cant. reducti-o¡ i-n responsiven€ss during all th:ee interrèsf:onsË t j-ne intervå1s. B€sides, th€ .!ìialdl_et and rl-atet int€Epclati-oû ccn¿iticrs effectecl a significaat increase in responses during interrgsp6¡se tines i¡tqedi-
ately iollcw:.ng ti¡û€ cut of th€ ÐÂtr d3]-ay. Àll th¡ee iût€rpcfat.sd caüilat€ stinulatictr faciLated thê effic -ency of DRt Ferf,cxnance b1' significânt1y íncEêasing th€ n€al) number of rËinforcene¡t3 pÊr r€sFonsê. The aùtho¡s tltus con.clìrd€d. Èåat tbere nas â stiFuLatico-indücê4 dis.ruptj-o¡l of noru¡a1 tiníêg process. Caudâ+-€ stj.üulation llnot only i¡hibi.ted resFonses during its occurrence blrt also oay have dis¡upt€d thê rBrìe orj.cr device ehich the ani.mals rornally utilj-zed to pEoc€ss inforeation about Èhe pas- sagë of ¡¡sstt (Ðêadvyler and $yêrs, 19701 . Chenica] S t i nü ]êt icn IxFërifents Dir€ct appLicaticn of c.Ì¡olinergic conpounds into the head of thê ca¡ldate rucl€ûs produc€d êffects sj.¡ai.lar to thosê €licitêil by eLect.rica.l srimulation" ItuIl €t at, {196?} ccmparêd the êifects of direct choli-nergic s+_ieuletio¡ of th€ heaü of th€ €âu(late nucleus {ith thôse bas€d cD el€ctrical sti.nulation of !hê sane area. Thsy found that FaEal"l-€1 tc e"l€ctrical stinu]atio¡ studiès, behavicural cGnsequenc€s of cartachol rere a f,unction of the tctê1 dose. Tfio qualitati!€ly dif ferelâÈ bchaviorrral patterãs €r€ cbser!ëd. ÀFFlj.catiûn of snô1l dosês {1êss than 4 tûg) of carbachal €licited xesponses ¡rhj.cà iocluded inhibitj,on ct on-qoj-ng l-€arn€d F€Efornânce al_though the animal renãin€d alert and respcnsive to sensory stieulj-. ¡{j.ghêr doses {ranging f ro¡n q to less than 10 mg) cn the oth€r hand, prrdüc€d behavioural effects ¡hi-ch incluiled j-ntense xag€, sevelg auto¡cEic ðischarge end sharp drcp 30
Page 1 and 2: U¡I IV EIì SIT T Og }lANTTI]BII T
Page 3 and 4: To Dr, Terrence p. Hogan, r4rhose d
Page 5 and 6: J. gÉcJrtyr€, D¡. V. fia¡rl.j-
Page 7 and 8: 4851RÀCT îJsieg the ccncêpÈ j-n
Page 9 and 10: ChaFter 1 nêvies of l,i t€ ra tu
Page 11 and 12: espons€ perfcrmaîce {Battig ,tos
Page 13 and 14: tail cf thê nuclèus. Kenp speciti
Page 15 and 16: espons€ lia various experimentê1
Page 17 and 18: iûemory of t Le di¡ecticnal cr€
Page 19 and 20: Test Açparatus. ]n the :rbait€dt
Page 21 and 22: sho!¡eC that (1) botà bilat.€ra
Page 23 and 24: aJìd prefrontal; Éost.erior caud
Page 25 and 26: oo.re plecise descríptj-cn cf tiì
Page 27 and 28: contrary to Èhê seco:ìd 1ësicn.
Page 29 and 30: enalns. Witä proLcnged stirula¿io
Page 31 and 32: Effects Õf tbe stiflìulaticn .n t
Page 33: vioural a:ìd êlect_rophysiolcgica
Page 37 and 38: they i¡¡bi.b!t dif f erent behavi
Page 39 and 40: dê1ayêd respÕ]]se ¡aìd t€epo
Page 41 and 42: subjec t s. üiles { t96q) rê}ûrt
Page 43 and 44: ¡ent in th task. Th€ se"êrj-t.y
Page 45 and 46: fashioD. Ècberts stat€d tbat tbe
Page 47 and 48: ather then thÐ reflex apparatus of
Page 49 and 50: perforn certaiD tasks. IhÈf shô*
Page 51 and 52: t_EÀ Dff ¡ìÞ llr TBE TIi TS SlT
Page 53 and 54: Frgura 2. À schenìatic diagram Ð
Page 55 and 56: the latter flill- carse a i¡crease
Page 57 and 58: a1l Ss {Hhj.ttiert Orx,1962), follo
Page 59 and 60: tion , a iailu¡e to rêspond durin
Page 61 and 62: . BE,HAVIORAL G ) MEASURE _ _ ___J
Page 63 and 64: ¡xp€riaental aesign: the ¡€la
Page 65 and 66: Èxpêrieê¡tal sessicn conpris€
Page 67 and 68: PSOCTDIJS! A. Delayed Conditj_on€
Page 69 and 70: Du.ring surgêrl, a scalp vas used
Page 71 and 72: a1 prûcedures lierê doûe j.r¡ t
Page 73 and 74: thê last pre-operativ€ day aåd
Page 75 and 76: considë¡aticì. .fôr a rdor€ d
Page 77 and 78: HhÊn thê sìlFerimposed .I/0 coDr
Page 79 and 80: actiyity colr:tter êtc, Ss j-! the
Page 81 and 82: Figure 4, t{ean of the totaL nueber
Page 83 and 84: Sigurs 5. l{€an of a) total l€v
Page 85 and 86:
Íigure 6. ïhe n€an Ëespc¡s€
Page 87 and 88:
3ì-gure ?. ThË d.if ferÈ¡ce pto
Page 89 and 90:
figurê 8. Þ- plot of the H CD on
Page 91 and 92:
Figurè 9" the phese p].ane repr€
Page 93:
Yigure 10, The phase diagran Õf be
Page 96 and 97:
-lP coO DP/DT i.60 (t-- -c I (t o -
Page 98 and 99:
.a r O< co,
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.00 16 .00 B l. 00 T ( ÞAYJ
Page 102 and 103:
î ) r(, tlJ I F = U) J I t rd o ul
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last t'¡o ti$ê blocks. These resu
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shorte¡ 1at€nciês ,the trajêct
Page 108 and 109:
(n td (n z. o o_ U) td É. J t-o F
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CAUDATE OPERATED CONTROL N=5 :::[ -
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Þro; - prl d. 00 0. 20 0. q0 -t C)
Page 114 and 115:
acLti+l',àn af t/o & rest svrger¡
Page 116 and 117:
ç ô F
Page 118 and 119:
_1 3ã coF
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a F Ë .9. ô DPlDT 0. ûrl o) -J -
Page 122 and 123:
-0.12 -0.10 -0. 0B DPlDT -0. 06 -0.
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oB jo- 10/¿c
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perrfìanent-l'y êtaxicrthough t¡
Page 128 and 129:
êspo¡sÈ of the slstem flas Colì
Page 130 and 131:
¡igure 24. l{ealì of tatal nünb
Page 132 and 133:
figure 25. The mêan of a) totâl l
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Figure 26. The ean respors€ laten
Page 136 and 137:
Figure 2?. Th€. differ€ncê Fl-
Page 138:
figurë 28. P Flot Õf Ð-1 syst€
Page 141 and 142:
',' O< O¿I æF
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16'r.00 2t..00 url.00 I'i. 00 T ( D
Page 145 and 146:
0uaJ o/1 {î foÍaÚ'¡z-\ I .sJ ¿
Page 147 and 148:
h0'0- IA/ ¿C
Page 149 and 150:
.n,vd, oJ t/o I, 1.68 P
Page 151 and 152:
LAST DAY ON DCA €-o CEREBELLAR SS
Page 153 and 154:
ìu$ber of rei¡forc€d 1€ver F
Page 155 and 156:
figure 35. Beans o'f altst-al lever
Page 157 and 158:
fj-guEê 36. Thê ¡Þêa¡¡ respo
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Figurê 37. P{0}-P{T) plct cf !-r c
Page 161 and 162:
Figur-- 38. P plct of ¡-I C an DC
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Fígure 39 P flot of t-.tr c group
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Figure 40 P plot of D-I c grcup ait
Page 167 and 168:
Pigure 41. Phase repres€ìtation
Page 169 and 170:
figure 42. Phase diagraB Ð{ t-f c
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figure .43. Phasè diagram of Ð-I
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GÊOüP V the group sÍtå bilatera
Page 175 and 176:
Pr€-operat j,qely the r€sFo¡se
Page 177 and 178:
FiguEê 49. Aciívity levêl of fro
Page 179 and 180:
figure 45. geans of total- I}r bÊr
Page 181 and 182:
I'igure 46. Effects of 2.5eg/r'kg d
Page 183 and 184:
Figure 4?. Þlean resporse låt€n
Page 185 and 186:
Figure ¡¡8. Ðiffer+nce plot I {0
Page 187 and 188:
Figüre 49. F pl-ot of th€ frcrta
Page 189 and 190:
'rigure 50" Phasè pla¡ìe reFrese
Page 191 and 192:
figure 51. P plot cf frÕntâl €y
Page 193 and 194:
figure 52. P plot of Érontal syst
Page 195 and 196:
figure 53. Phas€ dLagrâm .f lron
Page 197 and 198:
figure 54, lesioning. focüs around
Page 199 and 200:
gigure 55. EltinctiÕn curv€s of
Page 201 and 202:
GRoUP v.r the group *ith bil-at€r
Page 203 and 204:
Sj.gure 56" The neans of a) tctaL l
Page 205 and 206:
Figure 5?. ¡leân r€sponse lat
Page 207 and 208:
Figurê 58. titferÈnce plct of the
Page 209 and 210:
FiguEe 59. P çlot of the frontal s
Page 211 and 212:
¡'igu¡e 60. F plot cf the troãta
Page 213:
Figlrre 61. ? plct of the systeû s
Page 216 and 217:
-!l: _l O ne tnt 0. 00
Page 218 and 219:
¿ 09'1 I P O n) I P O F tl rcl 1\
Page 221 and 222:
cRoup vIT t*e qxoup ¡{ith bilãt
Page 223 and 224:
initial ¡egât:i-ve relative èrro
Page 225 and 226:
Y I LIJ II-þ ö P CD control n-3 m
Page 227 and 228:
(n L] (n ;Z o o_ (Ð Ld r J F o F [
Page 229 and 230:
1 () Ld 2 No Coireclionol Input C)
Page 231 and 232:
D I 'T: I - f tlJ 5-00 P r0) 3. 00
Page 234 and 235:
Tigure 68, P f lo+- of P CD systen
Page 236 and 237:
liEurë 59. P pl-ct oÍ P CD systë
Page 238 and 239:
figutre 70. thas€ plar¡e rep.res
Page 240 and 241:
figurê ?1. thase d.iagraûr e1èct
Page 242 and 243:
gigurê ?2. phase d j.agxam of P C
Page 244 and 245:
Figure 73. trxtj.!ìction cqrÌes o
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GROI¡P VIII the group ljith shan l
Page 248 and 249:
predomi.natj-ng forc: Õf erti.ncti
Page 250 and 251:
U) l! U) z o o- U) ¡.rJ E. J F o F
Page 252 and 253:
t Þ c õ' J g (D
Page 254 and 255:
_ P (T] 0-20 0.40 P (0) c0. 00
Page 257 and 258:
Fågure ?8. P llût of P cX C pcior
Page 259 and 260:
fÍgure 79. P plot cf P cD c subsê
Page 261 and 262:
Íigure 80" Phase dj-agra! cf P CÐ
Page 263:
yígure 81. ?hâs€ diagran of p C
Page 267 and 268:
GAOü.P VIITI the norcal control gr
Page 269 and 270:
p].ots of the N group bêfcr€ and
Page 271 and 272:
figure 84. th€ seans af al cèal
Page 273 and 274:
Figure 85. T!€ úean resçcnsê l
Page 275 and 276:
figure 86, The diff€Ë€nc€ pl
Page 277 and 278:
giEure 87. P p1Ðt af the ncrnaì s
Page 279 and 280:
FigurÐ 88. I plot of the Bor¡ìal
Page 281 and 282:
Figure 89. .P Flot of the rìornal
Page 283 and 284:
Figure 90. Phase diagran of the nor
Page 285 and 286:
figurê 9'l . Phesê ðiagraB ci th
Page 287 and 288:
Figüre 92. Phase plaae represenr-a
Page 289 and 290:
N TS ü1,Ì S: THB IiISTOI.OGÏCÀL
Page 291 and 292:
Th€ s€ct j-cns of the corpus c
Page 293 and 294:
Du€ tc the closeness of thê l*si
Page 295 and 296:
quadrant j.n th. right heaisçh€x
Page 297 and 298:
the lesianing cuErent prcdüceü a
Page 299 and 300:
figure 93. Ðiagrannìatj.c rÊpr+s
Page 301 and 302:
Ðj-agra$ Ð. À diagran ct a braiq
Page 303 and 304:
Ðiagram c.À diagran Ðf a brain s
Page 305 and 306:
Diagran 8. Ðiagraus cf brai¡ spec
Page 307 and 308:
Ðiagran À. A diagEar!ì af a bila
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'1:' t" rat # 85, sJ-ide -/ Z,area
Page 311 and 312:
at ,# 51 , slide 1J point of entry
Page 313 and 314:
_. \- I ¡ s lid.e ;f 14 slide # 15
Page 315 and 316:
Ea-. ¡at # 81, slide t' 4 rat ,.f
Page 317 and 318:
tu¡€s. Co¡ìsequently àher€
Page 319 and 320:
Ï/Ð ccntf,c1. Iio*eveE,i-h€ beh
Page 321 and 322:
voluntary u¡skil-I€d movenênts
Page 323 and 324:
nê¡nely tàê ahility -tro dêIay
Page 325 and 326:
The post-oFerative testíng sèssio
Page 327 and 328:
a!. d Erocks al-l- i.np1i*d th€ e
Page 329 and 330:
REFTASNCES âtlEian, E.Ð. After€
Page 331 and 332:
Inhibitcry ¡esponses to Lasal- gan
Page 333 and 334:
disordârs ct mcvement.I.cndo¡:Oxf
Page 335 and 336:
çross,C,Ð. Ccnpar j.sc¡ Ði thê
Page 337 and 338:
llarren E AN€rt{€ds.},T}€ Frc
Page 339 and 340:
of T €C€At ne sì or y a n å m
Page 341 and 342:
Nautard.J.¡l . Sc ìê etfereat cc
Page 343 and 344:
York: Ap FL€tcn-C€ntury cEsf ts
Page 345 and 346:
Toaonicr!Ì. :¡tlo. to nonlirìear
Page 347 and 348:
ÀPFTNDI T 1
Page 349 and 350:
tla lasz u se d the e.lastic spring
Page 351 and 352:
index is conput€d âad fêd ¡ack
Page 353 and 354:
tendencj.es cf a freqre¡cy distrib
Page 355 and 356:
the un knar¿n €q uaiio¡s. l{he
Page 357 and 358:
statistical êstimaticr, !chich doe
Page 359 and 360:
¿n9 of the bêhavioural systens lo
Page 361 and 362:
nois€s/cont an anants. ovÊraIl.,
Page 363:
CEREEEI-LUM IVlOTOR ÜCRTEX CONTROL
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The EffĘcts of In Partial 3ėĄLfil1n€nt of Tle B€qüireûents for Eh ...

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