Hyperbare Zuurstoftherapie: Rapid Assessment - KCE
Hyperbare Zuurstoftherapie: Rapid Assessment - KCE
Hyperbare Zuurstoftherapie: Rapid Assessment - KCE
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14 Hyperbaric Oxygenation Therapy <strong>KCE</strong> Reports 74<br />
3.2 LITERATURE SEARCHES ON CLINICAL EFFECTIVENESS<br />
Most of the randomised clinical trials have been done in small groups and for many of<br />
the indications no proper randomised trials have been performed. We therefore<br />
focussed our search on meta-analyses and systematic reviews.<br />
Relevant literature was sought in Medline, Embase, the Cochrane Database of<br />
Systematic Reviews (CDSR), and the DARE, NHS-EED and HTA databases of the<br />
Centre for Reviews and Dissemination (CRD). We also searched for ongoing clinical<br />
trials in the Cochrane Central Register for Controlled Trials. Details of strategy and<br />
search results can be found in the appendix. In addition we searched<br />
http://www.hboevidence.com/, a specialized site for EBM information on HBOT for the<br />
most recent information.<br />
3.3 DATA SOURCES<br />
From the 372 references of potential systematic reviews and meta-analyses retrieved<br />
originally, we selected, based on title and abstract, 104 articles for further<br />
consideration. From these we finally selected 54 references (see Figure 1 for details on<br />
selection). We also identified an additional article and a thesis through hand searching. 1,<br />
19<br />
Figure 1. Identification and selection of systematic reviews and Meta-<br />
Analyses<br />
Hand searching: 2<br />
Potentially relevant citations<br />
identified (Medline, Embase,<br />
Cochrane, CRD): 372<br />
Studies retrieved for more<br />
detailed evaluation: 104<br />
Relevant publications 54<br />
Publications selected: 56<br />
Based on title and abstract evaluation,<br />
citations excluded: 268<br />
Reasons:<br />
- Duplicate references (8)<br />
- Language (1)<br />
- Prior to 2000 (8)<br />
- Not relevant (56)<br />
- Single Clinical Trial (195)<br />
Based on full text evaluation, studies<br />
excluded: 50<br />
Reasons:<br />
- Not relevant (6)<br />
- Language (4)<br />
- Narrative review (30)<br />
- Guideline (2)<br />
- Duplicate content (8)<br />
The retained references included 17 Cochrane reviews published since 2002 and an<br />
Australian doctoral thesis from Michael Bennett who co-authored many of the<br />
Cochrane reviews. These 18 key references are listed in Table 4.