Hyperbare Zuurstoftherapie: Rapid Assessment - KCE
Hyperbare Zuurstoftherapie: Rapid Assessment - KCE
Hyperbare Zuurstoftherapie: Rapid Assessment - KCE
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<strong>KCE</strong> Reports 74 Hyperbaric Oxygenation Therapy 35<br />
The HAS, 37 the IECS, 38 and the AHRQ assessments come to similar conclusions. 14<br />
Within the COST B14 program (see before), a European RCT for HBOT in the acute<br />
treatment of sudden idiopathic sensorineural hearing loss (study co-ordinator: A.<br />
Barthelemy, Marseille, France) is reported to have started in September 2002 with<br />
seven centres participating and 56 patients have been included (information from<br />
2005). 42 However, no results have been found.<br />
3.4.12 Acute ophthalmological ischemia<br />
3.4.12.1 Short description of the condition<br />
Central retinal artery occlusion can result in a sudden interruption of the blood supply<br />
to the retina, causing unilateral loss of vision. This is a rare disease usually occurring<br />
between ages 50 to 80, with sudden, painless, a unilateral visual field defects, sometimes<br />
preceded by transient episodes of vision loss (amaurosis fugax). 61 This disease is most<br />
often cased by embolism of the retinal artery. Visual prognosis is poor and attempted<br />
treatment is based on medical treatment trying to improve perfusion of the retina.<br />
3.4.12.2 Summary of the evidence<br />
The ECHM considers HBOT optional in acute ophtalmological ischemia (type 3, level C<br />
recommendation). 9 The indication is not mentioned in the UHMS guidelines. 8 The HAS<br />
report takes over the ECHM recommendation, 37 while the IECS report refers to an<br />
uncontrolled pilot trial with 21 patients in Germany from Weinberger et al., but<br />
without solid conclusions. 38, 62 A STEER report from 2002 found only two retrospective<br />
comparisons of case series, one with 16 patients (eight with HBOT but without<br />
randomisation) and a second with 35 patients treated with HBOT compared to 37<br />
patients treated in a centre where no HBOT was available. The report concludes that<br />
no reliable evidence about the benefits of HOBT could be found in people with acute<br />
retinal ischemia. Again, it is concluded that RCTs are feasible and should be carried out.<br />
3.4.13 Neuroblastoma stage IV<br />
3.4.13.1 Short description of the condition<br />
Neuroblastoma is a cancer that arises in immature nerve cells and affects mostly infants<br />
and children. Stage 4 is a primary tumour with dissemination to distant lymph nodes,<br />
bone, bone marrow, liver, skin, and/or other organs. 63<br />
3.4.13.2 Summary of the evidence<br />
According to the ECHM, adjuvant HBOT for this indication should be considered<br />
although no RCTs are available to support this. 9 The UHMS does not mention this<br />
indication. 8<br />
The HAS report mainly follows the ECHM recommendation, 37 while neither the AHRQ<br />
14, 38<br />
nor the IECS report do not mention this indication.<br />
3.4.14 Pneumatosis Cystoides Intestinalis<br />
3.4.14.1 Short description of the condition<br />
Pneumatosis Cystoides Intestinalis (PCI) is a rare disease and describes the presence of<br />
gas-containing cysts in the bowel wall. It is a radiographic finding and not a diagnosis, as<br />
the aetiology varies from benign conditions to fulminant gastrointestinal disease. 64<br />
3.4.14.2 Summary of the evidence<br />
For the ECHM, HBOT may be used in selected cases of pneumatosis cystoides<br />
intestinalis as an alternative to surgery, when there is no sign of acute complications<br />
such as perforation, peritonitis and bowel necrosis (type 3, level C recommendation). 9<br />
The UHMS does not mention this indication in its guidelines. The HAS report mainly<br />
confirms the indication from ECHM, without additional evidence. 37