Hyperbare Zuurstoftherapie: Rapid Assessment - KCE
Hyperbare Zuurstoftherapie: Rapid Assessment - KCE
Hyperbare Zuurstoftherapie: Rapid Assessment - KCE
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<strong>KCE</strong> Reports 74 Hyperbaric Oxygenation Therapy 15<br />
Table 4. Cochrane reviews and thesis on various indications for hyperbaric<br />
oxygenation<br />
Title Year<br />
Recompression and adjunctive therapy for decompression illness. 20 2007<br />
Hyperbaric oxygen for idiopathic sudden sensorineural hearing loss and 2007<br />
tinnitus. 21<br />
Normobaric and hyperbaric oxygen therapy for migraine and cluster<br />
19, 22<br />
headache (Protocol)*.<br />
2007<br />
Hyperbaric oxygen as an adjuvant treatment for malignant otitis externa. 23 2005<br />
Hyperbaric oxygen for carbon monoxide poisoning. 24 2005<br />
Hyperbaric oxygen therapy for acute ischemic stroke. 25 2005<br />
Hyperbaric oxygen therapy for promoting fracture healing and treating<br />
fracture non-union. 26<br />
2005<br />
Hyperbaric oxygen therapy for late radiation tissue injury. 27 2005<br />
Hyperbaric oxygen therapy for acute coronary syndrome. 28 2005<br />
Hyperbaric oxygenation for tumour sensitisation to radiotherapy. 29 2005<br />
Hyperbaric oxygen therapy for delayed onset muscle soreness and closed<br />
soft tissue injury. 30<br />
2005<br />
Hyperbaric oxygen therapy for thermal burns. 31 2004<br />
Hyperbaric oxygen therapy for chronic wounds. 32 2004<br />
Hyperbaric oxygen therapy for the adjunctive treatment of traumatic brain 2004<br />
injury. 33<br />
Hyperbaric oxygen therapy for multiple sclerosis. 34 2004<br />
Non surgical interventions for late radiation proctitis in patients who have<br />
received radical radiotherapy to the pelvis. 35<br />
2002<br />
Interventions for replacing missing teeth: hyperbaric oxygen therapy for<br />
irradiated patients who require dental implants. 36<br />
2002<br />
Thesis: The Evidence Basis of Diving and Hyperbaric Medicine 1 2006<br />
* The formal Cochrane review is in press but results have been published by Schnabel et al. 19<br />
Our search also yielded several HTA reports. A few of the recent technology<br />
assessments covered the whole domain of HBOT. 14, 37, 38 Other HTA reports focussed<br />
on specific indications only, and will be addressed with the specific indications where<br />
relevant.<br />
The Cochrane Central Register for Controlled Trials reveals 20 registered RCTs<br />
between 2005 and 2007.<br />
Most of these trials investigate miscellaneous indications not-accepted by the two large<br />
hyperbaric medical communities, or therapies adjuvant to HBOT. Only two of these<br />
deal with CO intoxication (one RCT, 39 and a longitudinal study on affective outcome 40 )<br />
one deals with radio induced lesion, 17 and two with diabetic ulcers. 18, 41 The RCT<br />
database from the National Institutes of Health (NIH, www.clinicaltrials.gov) lists 31<br />
ongoing or recently completed trials on HBOT. A European Cost B14 program was<br />
started in 1998 and after prolongation ended in March 2005. 42 In addition to the<br />
development of a database, a common website (www.oxynet.org, a function now largely<br />
taken over by www.echm.org) and safety protocols for hyperbaric facilities, this<br />
collaboration also developed several research protocols for RCTs that were reportedly<br />
started in 2001 and 2002 (http://www.oxynet.org/ProtocolsIndex.htm). The status of<br />
these studies remains, however, unclear and it was confirmed that these RCTs were<br />
delayed due to lack of funding and are unlikely to provide results within the next 2 or 3<br />
years (personal communication D. Mathieu). Table 5 lists the RCTs currently in the NIH<br />
clinical trials database.