LIFE09200604007 Tabish - Homi Bhabha National Institute

Results
4.2.3.1 Percent G2 delay after γ-radiation exposure
A considerable G2 phase delay was observed in control cell lines while the
extent of G2 phase arrest was lower in MPN LCLs (Fig. 24, Fig. 25). The mean γ-
radiation -induced G2-phase accumulation in control cell lines was 19.18% at 5 Gy and
15.83% at 10 Gy which was significantly higher than the values for MPN cell lines
where mean G2 phase delay was 5.83% at 5 Gy and 3.86% at 10 Gy.
Fig. 24: Effect of γ-radiation exposure on MPN and control cell lines. Effect of radiation exposure on
MPN cell line (a) Effect of radiation exposure on control cell line (b).
The mean difference of percent G2 delay between the two groups was 13.35%
at 5 Gy and 11.97% at 10 Gy which was statistically significant with a p value=0.0001
at 5 Gy and p value=0.0017 at 10 Gy. A comparison between the two groups in terms
of difference in percent G2 delay at 5 Gy and 10 Gy radiation dose is shown in Table
10 (Fig. 26).
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