LIFE09200604007 Tabish - Homi Bhabha National Institute
LIFE09200604007 Tabish - Homi Bhabha National Institute
LIFE09200604007 Tabish - Homi Bhabha National Institute
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Review of Literature<br />
Fig. 2: Incidence of UADT cancer in Indian males. These cancers account approximately 40% of total<br />
male cancer burden with highest incidence and mortality (GLOBOCAN, 2008)<br />
Later in 1992, Day and Blot observed a 3.7% yearly rate for the onset of a<br />
second primary tumour in approximately 20,000 patients diagnosed with oral and<br />
pharyngeal cancer from nine population based registries from United States of<br />
America. Oral, pharyngeal and esophagous were the most common sites of second<br />
primary tumours followed by nose, larynx and lung and remaining were found in the<br />
lower digestive tract, the prostate, the urinary tract, the breast, and the female genital<br />
tract 24 . Other then head and neck cancers, MPN is a common feature of various<br />
inherited syndromes like, Li-Fraumani syndrome, hereditary breast ovarian cancer<br />
syndrome, Fanconi anaemia, Xeroderma pigmentosum and Blooms syndrome. While<br />
the cause for occurrence of MPN in above mentioned medical states is almost known<br />
the pathogenesis of UADT MPN is not completely understood making it one of the<br />
worst problems to deal with 25-28 .<br />
31