LIFE09200604007 Tabish - Homi Bhabha National Institute

Results
Table 14: Genotype-phenotype correlation between G Score (number of variant alleles) and
phenotypic responses after γ-radiation and BPDE exposure
Phenotype Genotype Score r value p value
Percent cell death
at 5 Gy
Percent cell death
at 10 Gy
Percent γ-H2AX
positive cells
(DNA repair at 2
Gy)
Percent γ-H2AX
positive cells
(DNA repair at 5
Gy)
Percent cell death
5μM BPDE
Total G Score -0.210 0.264
G Score DNA repair -0.361 0.049*
G Score MPN sign -0.235 0.210
Total G Score -0.291 0.118
G Score DNA repair -0.388 0.034*
G Score MPN sign -0.353 0.055 #
Total G Score 0.061 0.751
G Score DNA repair 0.104 0.588
G Score MPN sign -0.067 0.728
Total G Score 0.245 0.198
G Score DNA repair 0.181 0.346
G Score MPN sign -0.014 0.939
Total G Score -0.471 0.008*
G Score DNA repair -0.403 0.026*
G Score MPN sign -0.348 0.058 #
Percent cell death
8μM BPDE
Total G Score -0.462 0.010*
G Score DNA repair -0.412 0.023*
G Score MPN sign -0.334 0.070
Total G Score -0.214 0.255
G2 delay at 5 Gy
G Score DNA repair -0.519 0.003*
G Score MPN sign -0.451 0.012*
Total G Score -0.189 0.315
G2 delay at 10 Gy
G Score DNA repair -0.466 0.009*
G Score MPN sign -0.379 0.038*
Key: * p value significant (≤0.05), # Borderline significance
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